Staccato Prochlorperazine Single Dose PK Study

The objective of this study was to evaluate the tolerability, safety, and pharmacokinetics of
a single, inhaled dose of prochlorperazine (PCZ), administered as 1 or 2 puffs in healthy
young volunteers.

Inclusion Criteria:

- Subjects will be male or female subjects between the ages 18 to 45 years, inclusive in
good general health as determined by medical history, physical examination, 12-lead
ECG, spirometry, blood chemistry profile, hematology, urinalysis and in the opinion of
the Principal Investigator.

Exclusion Criteria:

- Subjects with a known history of allergy or intolerance to phenothiazines or related
drugs or who have any disease, by history, physical examination, or laboratory
abnormalities that in the investigator's opinion, would present undue risk to the
subject, or may confound the interpretation of study results.