Bioavailability of Pepper Carotenoids in Humans
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 10/14/2017 |
| Start Date: | September 2007 |
| End Date: | June 30, 2010 |
- list item one, Peppers
We propose to evaluate bio absorption of pepper carotenoids in a red bell-pepper or
non-pungent green jalapeno pepper. The pepper will be provided in a cooked dish. The specific
aims of this study are: 1) to determine blood response kinetics of lutein following multiple
doses of non-pungent green jalapeno pepper with meals. 2) to determine blood response
kinetics of zeaxanthin/capsanthin following multiple doses of red bell pepper with meals. We
will feed 16 healthy man and women (50 - 65 y, females were at least one year post
menopause), each cooked green jalapeno pepper or red pepper for 4 days and donate blood
samples up to 21 days to determine blood response kinetics of xanthophylls following multiple
doses of pepper dishes.
We propose to evaluate bio absorption of pepper carotenoids in a red bell-pepper or
non-pungent green jalapeno pepper. The pepper will be provided in a cooked dish. The specific
aims of this study are: 1) to determine blood response kinetics of lutein following multiple
doses of non-pungent green jalapeno pepper with meals. 2) to determine blood response
kinetics of zeaxanthin/capsanthin following multiple doses of red bell pepper with meals. We
will feed 16 healthy man and women (50 - 65 y, females were at least one year post
menopause), each cooked green jalapeno pepper or red pepper for 4 days and donate blood
samples up to 21 days to determine blood response kinetics of xanthophylls following multiple
doses of pepper dishes.
- list item one, Peppers
Epidemiological data show that carotenoids and ß-C are health promoting when taken at
physiologic levels in foods. However, human absorption and metabolism of carotenoids
contained in various food matrices has not been studied well. It is important to investigate
the characteristics of absorption and disposal kinetics after eating carotenoid rich foods in
order to gain a basic understanding of the biological characteristics of lutein, zeaxanthin,
and other carotenoids in food sources.
We propose to evaluate bio absorption of pepper carotenoids in a 2-phase research study:
phase 1 will utilize red bell-pepper and phase 2 will utilize non-pungent green jalapeno
pepper. The pepper will be provided as a dish in a meal. We will feed 16 healthy man and
women (50 - 70 y, females were at least one year post menopause), each with red pepper (phase
1) and/or green jalapeno pepper (phase 2) for ~ 4 days and donate blood samples up to 21
days. Volunteers will be randomly assigned to one of the following two phases: phase 1 and
phase 2.
The study will provide us the information on the bioavailability of pepper carotenoids.
Epidemiological data show that carotenoids and ß-C are health promoting when taken at
physiologic levels in foods. However, human absorption and metabolism of carotenoids
contained in various food matrices has not been studied well. It is important to investigate
the characteristics of absorption and disposal kinetics after eating carotenoid rich foods in
order to gain a basic understanding of the biological characteristics of lutein, zeaxanthin,
and other carotenoids in food sources.
We propose to evaluate bio absorption of pepper carotenoids in a 2-phase research study:
phase 1 will utilize red bell-pepper and phase 2 will utilize non-pungent green jalapeno
pepper. The pepper will be provided as a dish in a meal. We will feed 16 healthy man and
women (50 - 70 y, females were at least one year post menopause), each with red pepper (phase
1) and/or green jalapeno pepper (phase 2) for ~ 4 days and donate blood samples up to 21
days. Volunteers will be randomly assigned to one of the following two phases: phase 1 and
phase 2.
The study will provide us the information on the bioavailability of pepper carotenoids.
Inclusion Criteria:
- healthy volunteers
Exclusion Criteria:
- GI track problems
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