Ocular Availability in Human Tears After Topical Administration of 1.5% Levofloxacin Compared to Active Comparators

Inclusion Criteria:

- Be willing and able to provide written informed consent and HIPAA indicating that they
understand the purpose of and procedures required for the study and are willing to
participate in the study

- Be willing and able to follow all instructions and attend all study visits

- If female and of childbearing potential, not be pregnant, nursing or planning a
pregnancy and agree to submit to a pregnancy test. The result of the test must be
negative and female subjects of childbearing potential must also agree to use an
acceptable method of contraception for the duration of the study (acceptable method of
contraception includes oral, implantable, transdermal, or injectible contraceptives,
spermicide with barrier, IUD, or surgical sterilization of partner)

Exclusion Criteria:

- Have a known allergy and/or sensitivity to the test article(s) or its components or
any therapies associated with the study

- Have active signs or symptoms of any clinically significant ocular disorder (other
than refractive disorders)

- Have a history of dry eye syndrome

- Use disallowed medications (systemic or topical) (i.e. any fluoroquinolone
anti-infective agents or any topical ophthalmic products) during the appropriate
pre-study washout period and during the study.

- Be a contact lens wearer who is unwilling to forego contact lens wear within 3 days
prior to the start of the study and for the duration of the study

- Have had any ocular surgical intervention 12 months prior to the study or anticipate
having ocular surgery during the study

- Be pregnant or nursing women; or women who have a positive urine pregnancy test at
screening or women of childbearing potential who refuse to use an adequate hormonal or
mechanical means of birth control

- Be concurrently enrolled in an investigational drug or device study or have used an
investigational drug or device within 30 days of entry into this study

- Employees of the investigator or study center, with direct involvement in th proposed
study or other studies under the direction of that investigator or study center, as
well as family members of the employees or the investigator.