A Study of SB-742457, Added to Donepezil for the Treatment of Mild-to-moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 85
Updated:12/9/2017
Start Date:July 1, 2008
End Date:November 16, 2010

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Study AZ3110866, a Fixed Dose Study of SB-742457 Versus Placebo When Added to Existing Donepezil Treatment in Subjects With Mild-to-moderate Alzheimer's Disease

The study is designed to investigate the safety and efficacy of SB-742457 when added to
stable donepezil treatment in subjects with mild-to-moderate Alzheimer's disease.


Inclusion Criteria:

- Subjects and their caregivers must provide informed consent prior to study entry.

- Subjects must have a clinical diagnosis of probable mild-to-moderate Alzheimer's
disease with no evidence of disorders that are thought to be the cause of, or
contributing to the severity of the subject's dementia and a documented history of at
least 6 months of ongoing donepezil therapy with stable dosing for at least the last 2
months.

- Subjects must have a regular caregiver who is willing to attend visits, oversee the
subject's compliance with the study and report on the subject's status.

- Female subjects of child-bearing potential must agree to abstinence or an approved
form of birth control.

- Subjects must have adequate blood pressure and laboratory values.

Exclusion Criteria:

- Subjects with a diagnosis of possible, probable or definite vascular dementia may not
participate.

- Subjects with known hypersensitivity to sunlight or a history of seizures, previous
exposure to SB-742457, taking agents for which there is a theoretical risk of
interaction with SB-742457, or taking medication for Alzheimer's disease or centrally
acting agents which might impact study outcomes may not participate.
We found this trial at
15
sites
Bennington, Vermont 05201
547
mi
from 43215
Bennington, VT
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Austin, Texas 78705
1064
mi
from 43215
Austin, TX
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Ciudad Autonoma de Buenos Aires, Buenos Aires
5386
mi
from 43215
Ciudad Autonoma de Buenos Aires,
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Columbus, Ohio 43219
7
mi
from 43215
Columbus, OH
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Fresno, California 93720
1986
mi
from 43215
Fresno, CA
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Hallandale Beach, Florida 33009
980
mi
from 43215
Hallandale Beach, FL
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Hialeah, Florida 33013
987
mi
from 43215
Hialeah, FL
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Litchfield Park, Arizona 85340
1676
mi
from 43215
Litchfield Park, AZ
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Manchester, New Jersey 08759
457
mi
from 43215
Manchester, NJ
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Memphis, Tennessee 38120
501
mi
from 43215
Memphis, TN
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Rancho Mirage, California 92270
1883
mi
from 43215
Rancho Mirage, CA
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San Francisco, California 94115
2108
mi
from 43215
San Francisco, CA
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Syracuse, New York 13210
414
mi
from 43215
Syracuse, NY
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Tulsa, Oklahoma 74105
752
mi
from 43215
Tulsa, OK
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Winston-Salem, North Carolina 27103
307
mi
from 43215
Winston-Salem, NC
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