Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
| Status: | Completed |
|---|---|
| Conditions: | Smoking Cessation, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 9/16/2018 |
| Start Date: | May 2008 |
| End Date: | September 2009 |
In heavy marijuana smokers, opioid receptor blockade increases the subjective and
cardiovascular effects of marijuana. The current study was designed to clarify
opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function
for marijuana-elicited effects in heavy marijuana smokers. For this within-subject,
double-blind study, a marijuana smoking procedure was designed to characterize a
dose-response relationship for marijuana's subjective and cardiovascular effects under
blinded conditions.
cardiovascular effects of marijuana. The current study was designed to clarify
opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function
for marijuana-elicited effects in heavy marijuana smokers. For this within-subject,
double-blind study, a marijuana smoking procedure was designed to characterize a
dose-response relationship for marijuana's subjective and cardiovascular effects under
blinded conditions.
Inclusion Criteria:
- Current marijuana use
- Able to perform study procedures
- Women practicing an effective form of birth control
Exclusion Criteria:
- Current repeated illicit drug use (other than marijuana)
- Presence of significant medical illness (e.g., diabetes, cardiovascular
disease,hypertension, hepatitis, clinically significant laboratory abnormalities, LFTs
> 3x upper limit of normal, blood pressure > 140/90
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New York State Psychiatric Institute The New York State Psychiatric Institute (NYSPI), established in 1895,...
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