Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 12/24/2017 |
| Start Date: | December 2007 |
| End Date: | December 2013 |
This study proposes to investigate whether treatment with minocycline pre-operatively in
patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce
the occurence of kidney injury.
patients with mild to moderate chronic kidney disease undergoing cardiac surgery will reduce
the occurence of kidney injury.
Inclusion Criteria:
- Age over 18 years
- planned CABG or valvular surgery with cardiopulmonary bypass
- Serum creatinine available (within 30 days)
- Estimated GFR 15-90ml/min using the abbreviated MDRD formula (CKD stages 2-4)
Exclusion Criteria:
- Emergent or urgent surgery (to be performed within the next 36 hours)
- End stage renal disease, or GFR < 15ml/min (CKD stage 5)
- Estimated GFR>90ml/min (CKD stage 1 or no CKD)
- Ongoing infection by positive blood, urine or sputum cultures or pneumonia on CXR
- Allergy to minocycline or tetracyclines
- inability to take oral medications
- use of preoperative vasopressor agents at therapeutic doses
- Pregnant or lactating females
- Advanced liver disease by history or exam(cirrhosis, ascitis, jaundice)
- Rising creatinine meeting the definition of acute kidney injury prior to surgery
- Neurologic signs or symptoms or history of increased intracranial pressure
- current participation in another research study involving an investigational drug or
device
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Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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