A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot Study
| Status: | Completed |
|---|---|
| Conditions: | Cognitive Studies, Anemia |
| Therapuetic Areas: | Hematology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 8 - 18 |
| Updated: | 10/14/2017 |
| Start Date: | September 2003 |
| End Date: | December 2014 |
The overall goal of this project is to determine the feasibility of conducting a cognitive
intervention for children with sickle cell disease.
intervention for children with sickle cell disease.
The primary aims of this clinical trial are:
1. Determine the effectiveness of targeted learning and memory strategy remediation in
students with sickle cell disease and cognitive deficits.
2. Determine if there is improvement in academic achievement after targeted memory strategy
remediation.
1. Determine the effectiveness of targeted learning and memory strategy remediation in
students with sickle cell disease and cognitive deficits.
2. Determine if there is improvement in academic achievement after targeted memory strategy
remediation.
Inclusion Criteria:
- Sickle cell disease that is confirmed by hemoglobin analysis
- Has a brain magnetic resonance imaging (MRI) document reading by a neuroradiologist
- Cognitive deficits, which are defined by one standard deviation lower than the normal
ranges of an age-based standard score in cognitive tests that are evaluated by a
psychologist
- Must be a student who will remain in school for at least 2 years
- Must provide informed consent with assent in accordance with the institutional
policies (institutional review board approval)
Exclusion Criteria:
- Known developmental delays (these participants are ineligible because their learning
potential may be biased from a prior insult)
- Intelligent quotient is less than 50 (may have impaired learning potential)
- Aphasic (i.e., unable to produce intelligible speech)
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