Comparison of Oral Dexamethasone Doses in Asthma Exacerbation

Asthma has become a major public health problem of increasing concern in the US as it is the
most prevalent chronic disease of childhood with over 6 million children under the age of 17
affected 7. Low-income populations, minorities, and children living in inner cities
experience disproportionately higher morbidity and mortality due to asthma. Children who
suffer from asthma often present to the ED or outpatient center for management of their
symptoms and exacerbations. Asthma related ED visits in 2004 were estimated at 1.8 million,
with children younger than 17 accounting for almost half with 754,000 visits 7 Recent
clinical trials have shown the efficacy of dexamethasone in the ED management of asthma. In
Quereshi et al, a randomized study of 533 patients showed that two doses of DEX taken on days
1 and 2 were equally efficacious as 5 days of prednisolone2. However, patients treated with
DEX demonstrated improved compliance with less vomiting, fewer missed days of school and
fewer missed parental workdays. A more recent study by Altamimi et al compared single dose
DEX to 5-day prednisolone1. This double blinded, randomized prospective study of 134 children
concluded that single dose DEX is no worse than 5 days of prednisolone as well.dexamethasone
in the acute management of asthma exacerbation. However, practices vary as to the use of
single dose, two-day dosing and when to administer the second dose. The purpose of this study
is to compare various dosing regimes of dexamethasone in its efficacy in the treatment of
asthma exacerbations. Given the longer duration of action of DEX (36-72 hours), we
hypothesize that 2 doses of DEX given on days 1 & 3 are superior to single dose DEX in
improving symptoms and preventing relapse in the ED management of mild to moderate asthma
exacerbations.

These previous studies show similar efficacy of dexamethasone when compared to the standard
5-day prednisone/prednisolone treatment. . Within the institution, the investigators have
incorporated the use of dexamethasone in the management of acute asthma exacerbations.
However, practices vary as to the use of a single dose, two-day dosing and the timing of the
second dose for those patients receiving two doses of dexamethasone.

The purpose of this study was to determine if single dose oral dexamethasone is as effective
as a 2 dose course of oral dexamethasone in preventing relapse within 7 days for pediatric
asthma patients managed in the ED. Given the long half life of dexamethasone, the
investigators hypothesized that 2 doses given on days 1 and 3 are superior to single dose in
improving symptoms and preventing relapse in the ED management of mild to moderate asthma
exacerbations.

Inclusion Criteria:

- children 2-17 years old

- with a history of wheezing (> 1 episode requiring ß-2 agonist therapy) who present to
the ED with mild to moderate asthma exacerbations

*mild-moderate exacerbations are defined as a RSS < 11

- patients whose symptoms do not resolve after the first albuterol/atrovent treatment
(given in the ED, or at home or via EMS within 1 hour prior to arrival to the ED) are
eligible for enrollment

Exclusion Criteria:

- age < 2 years due to overlap with bronchiolitis

- use of steroids within 3 weeks

- recent exposure to TB, varicella, or herpes

- active varicella/herpes infections

- concomitant stridor, vomited 2 doses in ED

- severe asthma as defined by RSS > 12

- requirement for or pre-existing IV access

- need for immediate airway protection

- history of intubations for asthma or comorbidities (Chronic Lung Disease (CLD),
Congenital Heart Defects (CHD), or neurologic disorders)