Validation of a New Shortness of Breath With Daily Activities Questionnaire in Patients With Chronic Obstructive Pulmonary Disease

Dyspnea, referred to by patients as "shortness of breath" or "breathlessness," is frequently
associated with decreases in functional status, quality of life, and disabilities. Currently
available questionnaires do not specifically address the shortness of breath component of
COPD. The development of a patient reported outcome questionnaire that will specifically
assess Shortness of Breath with Daily Activities (SOBDA) in patients with COPD is needed.

Inclusion Criteria:

- Adults ≥ 40 years of age

- Established clinical history of COPD by ATS/ERS definition

- Former or current smoker > 10 pack years

- Evidence of dyspnea

Exclusion Criteria:

- Has a respiratory disorder other than COPD

- Cancer not in complete clinical remission

- Clinically significant cardiovascular, neurological, psychiatric, renal,
gastro-intestinal, immunological, endocrine, or hematological abnormalities that are
uncontrolled