Rifaximin for the Treatment of Persistent Symptoms in Patients With Celiac Disease
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/14/2017 |
| Start Date: | October 2006 |
| End Date: | April 2008 |
Double-blind Randomized Controlled Trial of Rifaximin for Persistent Symptoms in Patients With Celiac Disease
Celiac disease is a condition in which the small intestine is damaged by gluten, the storage
protein of wheat and similar proteins in barley and rye. The disease can cause different
symptoms such as diarrhea, bloating, abdominal pain and weight loss. The majority of patients
respond to a gluten-free diet. However some patients (5-30%) have persistent symptoms and are
considered to be poor responders to the diet. Bacterial overgrowth in the small intestine
accounts for some of the refractory patients.
This study seeks to determine if antibiotic therapy with rifaximin relieves the symptoms of
patients who are poorly responsive to a gluten-free diet and whether this impacts their
breath test results.
protein of wheat and similar proteins in barley and rye. The disease can cause different
symptoms such as diarrhea, bloating, abdominal pain and weight loss. The majority of patients
respond to a gluten-free diet. However some patients (5-30%) have persistent symptoms and are
considered to be poor responders to the diet. Bacterial overgrowth in the small intestine
accounts for some of the refractory patients.
This study seeks to determine if antibiotic therapy with rifaximin relieves the symptoms of
patients who are poorly responsive to a gluten-free diet and whether this impacts their
breath test results.
A symptom questionnaire will be administered at study initiation, 2 weeks and 12 weeks.
Patients will undergo a breath test which involves drinking a sugar (lactulose) solution and
breathing into a machine. This technique will identify the presence of bacteria in the small
intestine. They will be randomly selected to receive either an antibiotic (rifaximin) or
placebo three times a day for 10 days to treat their bacterial overgrowth.
Patients will undergo a breath test which involves drinking a sugar (lactulose) solution and
breathing into a machine. This technique will identify the presence of bacteria in the small
intestine. They will be randomly selected to receive either an antibiotic (rifaximin) or
placebo three times a day for 10 days to treat their bacterial overgrowth.
Inclusion Criteria:
- Adult patients age 18 or older
- Biopsy proven celiac disease
- Persistent symptoms of diarrhea, gas, bloating and/or cramping despite a gluten free
diet for at least 1 month
- Women that are not pregnant or lactating can be included. All women must have a
documented negative pregnancy test at the initiation of the study. Women who become
pregnant during the study will be asked to discontinue the study drug and will be
followed up until the outcome of pregnancy is known. Women of child bearing potential
must be practicing an effective method of birth control (eg: prescription oral
contraceptive, contraceptive injections, intra-uterine device, double barrier method,
contraceptive patch, male sterilization) before entry and throughout the treatment
period.
Exclusion Criteria:
1. antibiotic use for any indication within preceding one month
2. use of bismuth compounds within preceding month
3. concomitant use of pancreatic supplements
4. concomitant use of antispasmodics
5. concomitant use of immunomodulators such as corticosteroids, budesonide, alkylating
agents and antimetabolites.
6. concomitant use of probiotics
7. concomitant use of prokinetic agents
8. concomitant use of 5HT3 antagonists, 5HT4 agonists
9. concomitant use of antimotility agents (e.g loperamide)
10. concomitant use of antidiarrheal agents
11. diagnosed microscopic colitis or inflammatory bowel disease
12. other causes of malabsorption: pancreatic insufficiency, giardiasis and enteropathy
associated with T cell lymphoma.
13. other diseases: renal or hepatic insufficiency.
14. pregnant patients and lactating females. In addition women of child bearing age will
be excluded if they are not using one of the methods of contraception like oral
contraceptives, IUD and double barrier methods.
15. patients with tuberculosis or a positive PPD test and infection with other
mycobaterial diseases.
16. allergy and/or potential emergence of drug resistance to rifampicin and rafamycin
compounds.
We found this trial at
1
site
Click here to add this to my saved trials
