Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System

Comparative evaluation of AG200-15 versus OC with regard to safety, contraceptive efficacy,
cycle control (bleeding pattern), subject compliance and serum concentrations of EE and LNG.
To evaluate TCDS wearability (including adhesion).

Inclusion Criteria:

Healthy females

- 17(in states where the legal age of consent to receive contraceptives is 17)-40 years

- Regular, consistent menstrual cycles between 25 and 35 days

- Sexually active women requesting birth control

- In good general health, confirmed by medical history, physical (including gynecologic)
examination and screening laboratory values

Exclusion Criteria:

- Known or suspected pregnancy;

- Lactating women

- Significant skin reaction to transdermal preparations or sensitivity to surgical /
medical tape

- Any disease that may worsen under hormonal treatment (cardiovascular, liver,
metabolic)

- Use of other contraceptive methods than study medication