Sleepiness and the Effects of CPAP on Salivary Cortisol and Alpha-Amylase Levels in Patients With Sleep Apnea
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 10/14/2017 |
| Start Date: | November 2004 |
| End Date: | December 2011 |
Patients with Obstructive Sleep Apnea Syndrome (OSAS) will evidence higher levels of salivary
cortisol and alpha-amylase levels prior to use of placebo and continuous positive airway
pressure (CPAP) and will evidence a decrease in these levels after consistent use of
continuous positive airway pressure (CPAP) therapy as compared to placebo. Their level of
sleepiness will also decrease with the use of CPAP therapy and will correlate with the levels
of salivary cortisol and alpha-amylase in relation to their subjective sleepiness scale,
Psychomotor Vigilance Test (PVT), and pupillometry.
cortisol and alpha-amylase levels prior to use of placebo and continuous positive airway
pressure (CPAP) and will evidence a decrease in these levels after consistent use of
continuous positive airway pressure (CPAP) therapy as compared to placebo. Their level of
sleepiness will also decrease with the use of CPAP therapy and will correlate with the levels
of salivary cortisol and alpha-amylase in relation to their subjective sleepiness scale,
Psychomotor Vigilance Test (PVT), and pupillometry.
It has been shown that there is an inconsistent response in serum cortisol levels in patients
with Obstructive Sleep Apnea Syndrome (OSAS), but it is undetermined whether a change in
hormone level was not seen due to compliance issues in these long-term studies. These
investigators will be employing compliance monitoring continuous positive airway pressure
(CPAP) machines and also assessing "sleepiness" before and after therapy. Sleepiness is the
dependent variable in our study and will be measured subjectively using sleepiness scales and
objectively using Psychomotor Vigilance Test (PVT) and an autonomic measure using
pupillometry prior, during and after treatment.
with Obstructive Sleep Apnea Syndrome (OSAS), but it is undetermined whether a change in
hormone level was not seen due to compliance issues in these long-term studies. These
investigators will be employing compliance monitoring continuous positive airway pressure
(CPAP) machines and also assessing "sleepiness" before and after therapy. Sleepiness is the
dependent variable in our study and will be measured subjectively using sleepiness scales and
objectively using Psychomotor Vigilance Test (PVT) and an autonomic measure using
pupillometry prior, during and after treatment.
Inclusion Criteria:
- Adults
- Male and female
- Between ages 18 and 90
- Undergo a Polysomnography (PSG) with evidence of any sleep disordered breathing
including snoring, mild/moderate/severe sleep apnea, and/or restless legs
Exclusion Criteria:
- Ages 17 and under
- Pregnant women
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