Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers

During Dosing Period 1, blood samples for pharmacokinetic (PK) analysis will be obtained
predose (15 minutes prior to administration of EXPAREL) through 12 hours postdose (i.e., at
15 and 30 minutes, 1, 2, 4, 8, and 12 hours) for Cohort 4; through 36 hours postdose (i.e.,
at 15 and 30 minutes, 1, 2, 4, 8, 12, 24, and 36 hours) for Cohort 3; through 60 hours
postdose (i.e., at 15 and 30 minutes, 1, 2, 4, 8, 12, 24, 36, 48, and 60 hours) for Cohort 2;
and through 72 hours postdose (i.e., at 15 and 30 minutes, 1, 2, 4, 8, 12, 24, 36, 48, 60,
and 72 hours) for Cohorts 1 and 5.

During Dosing Period 2 (Cohorts 2, 3, and 4 only), blood samples for PK analysis will be
obtained predose (15 minutes prior to administration of EXPAREL) through 72 hours postdose
(i.e., at 15 and 30 minutes, 1, 2, 4, 8, 12, 24, 36, 48, 60, and 72 hours).

Inclusion Criteria:

- Males or females ≥18 years of age.

- American Society of Anesthesiologists (ASA) physical status 1 or 2.

- Female subjects must be surgically sterile, at least 2 years postmenopausal, or using
a medically acceptable method of birth control. If of childbearing potential, must
have a documented negative pregnancy test within 24 hours before the first study drug
administration.

- Able to provide informed consent, adhere to the study visit schedule, and complete all
study assessments.

Exclusion Criteria:

- History of hypersensitivity or idiosyncratic reactions to amide-type local
anesthetics.

- History of abnormal bleeding tendencies/clotting disorders.

- Regular use of anticoagulants (except for low dose aspirin for cardioprotection).

- Received any investigational drug within 30 days prior to study drug administration,
and/or has planned administration of another investigational product or procedure
during his/her participation in this study.

- Currently pregnant, nursing, or planning to become pregnant during the study or within
1 month after study drug administration.

- Subjects with significant medical conditions or laboratory results that, in the
opinion of the Investigator, would constitute a contraindication to participation in
the study, or cause inability to comply with the study requirements.

- Received bupivacaine or other local anesthetic within 7 days of first study drug
administration.