Identification and Referral of Women at Risk for Hereditary Breast/Ovarian Cancer
| Status: | Completed |
|---|---|
| Conditions: | Ovarian Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/22/2018 |
| Start Date: | April 2016 |
| End Date: | February 28, 2018 |
Strategies to Increase the Identification, Genetic Counseling Referral and Genetic Testing for Women at Risk for Hereditary Breast and/or Ovarian Cancer
The purpose of this study is to identify the most effective means of follow-up for women who
screen positive on B-RST (Breast Cancer Genetics Referral Screening Tool) applied in the
standard clinical setting of mammography, to maximize the number who are referred to and
receive cancer genetic counseling services. The clinical utility of B-RST 3.0 will also be
evaluated by determining the number seen who are appropriate for genetic testing, undergo
genetic testing and are found to carry a hereditary cancer gene mutations with medical
management implications for the patient and family. The long-term goal is to reduce the
morbidity and mortality associated with hereditary causes of breast and ovarian cancer among
patients seen in the Emory/Winship system.
screen positive on B-RST (Breast Cancer Genetics Referral Screening Tool) applied in the
standard clinical setting of mammography, to maximize the number who are referred to and
receive cancer genetic counseling services. The clinical utility of B-RST 3.0 will also be
evaluated by determining the number seen who are appropriate for genetic testing, undergo
genetic testing and are found to carry a hereditary cancer gene mutations with medical
management implications for the patient and family. The long-term goal is to reduce the
morbidity and mortality associated with hereditary causes of breast and ovarian cancer among
patients seen in the Emory/Winship system.
The three aims for this study are: 1. To develop an electronic version of the revised B-RST
(Breast Cancer Genetics Referral Screening Tool) with a HIPAA compliant database for
integration within the Winship Cancer Institute at Emory website. 2. To identify the most
effective means of follow-up to maximize the number of screen positive individuals who are
referred to and complete cancer genetics counseling. 3. Evaluate the clinical utility of
B-RST 3.0 by analyzing the number of individuals who were referred to and received genetic
counseling and were considered appropriate for genetic testing and underwent genetic testing,
and were identified with a BRCA1/2 mutation, and/or were identified with a mutation in a
different hereditary cancer gene, or were not appropriate for genetic testing, but were
appropriate for referral to high-risk follow-up services.
The B-RST is a simple yet effective screening tool to identify individuals who may be at risk
for hereditary breast and ovarian cancer. This study will seek to determine the most
effective method of follow-up to maximize referral to and completion of cancer genetic
counseling services following a screen positive result on the B-RST tool, and to understand
clinical outcomes following participation in genetic counseling (i.e., whether patients who
receive counseling undergo genetic testing, genetic testing results, and recommendations for
enhanced screening and preventions).
(Breast Cancer Genetics Referral Screening Tool) with a HIPAA compliant database for
integration within the Winship Cancer Institute at Emory website. 2. To identify the most
effective means of follow-up to maximize the number of screen positive individuals who are
referred to and complete cancer genetics counseling. 3. Evaluate the clinical utility of
B-RST 3.0 by analyzing the number of individuals who were referred to and received genetic
counseling and were considered appropriate for genetic testing and underwent genetic testing,
and were identified with a BRCA1/2 mutation, and/or were identified with a mutation in a
different hereditary cancer gene, or were not appropriate for genetic testing, but were
appropriate for referral to high-risk follow-up services.
The B-RST is a simple yet effective screening tool to identify individuals who may be at risk
for hereditary breast and ovarian cancer. This study will seek to determine the most
effective method of follow-up to maximize referral to and completion of cancer genetic
counseling services following a screen positive result on the B-RST tool, and to understand
clinical outcomes following participation in genetic counseling (i.e., whether patients who
receive counseling undergo genetic testing, genetic testing results, and recommendations for
enhanced screening and preventions).
Inclusion Criteria:
- Patient at one of the participating clinics (Winship Cancer Institute and Emory
University Hospital Midtown) who arrive for a screening mammogram appointment.
Exclusion Criteria:
- Patients receiving a diagnostic mammogram will not be invited to participate in the
study.
We found this trial at
2
sites
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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