Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction

Subject will undergo standard clinical protocols for the entire oocyte stimulation cycle and
all assisted reproductive procedure decisions and algorithms will be decided entirely
independent of this study.

The anesthetic and postoperative pain regimens will use the same agents and dose ranges used
in clinical standard practice; however, the regimens will be standardized, so as to limit
confounding variables. The study regimen for anesthesia will differ from the current,
clinical standard by the mandated use of actual body weight (in current practice, actual,
adjusted ideal, or ideal body weights are used), the use of fentanyl 1 mcg/kg IV (instead of
100 mcg for everyone), and the standardization of postoperative analgesia (noted below). The
total amount of fentanyl, propofol, and postoperative drugs will be recorded.

Postoperative analgesia will be standardized based on the subject's self reported verbal
analogue score (VAS) and the timing of the report. The agents and timing used below differ
from the current clinical standard by assessing VAS and responding with a certain regimen.

Inclusion Criteria:

- American Society of Anesthesiologists (ASA) I to III health status (moderate systemic
disease),

- Age between 18 and 50 yrs

- Undergoing oocyte retrieval with intravenous general anesthesia.

Exclusion Criteria:

- Refuse or withdraw their consent

- Fail to adequately respond to IVF stimulations medications, and thus are not eligible
for oocyte retrieval.