A Study of Lasmiditan in Healthy Participants When Co-administered With Topiramate

Inclusion Criteria:

- Are healthy males or females (of non-child bearing potential), as determined by
medical history and physical examination

- Have a body mass index of 19.0 to 35.0 kilograms per meter squared (kg/m²) inclusive

Exclusion Criteria:

- Have known allergies to lasmiditan, topiramate, related compounds or any components of
the formulation of lasmiditan or topiramate

- Have an abnormal supine blood pressure, defined as systolic blood pressure less than
(<) 90 or great (>) 140 millimeters of mercury (mmHg) or diastolic blood pressure <60
or >90 mmHg at screening

- Have known or ongoing psychiatric disorders considered clinically significant by the
investigator or demonstrate suicidal ideation on the Columbia Suicide Severity Rating
Scale (C-SSRS)

- Have a clinically significant abnormality in the neurological examination

- Have current or a history of orthostatic hypotension (>20-mmHg drop in systolic blood
pressure, or >10-mmHg drop in diastolic blood pressure) with or without dizziness
and/or syncope at screening or admission to the Clinical Research Unit (CRU) upon
repeat testing

- Have an estimated glomerular filtration rate using Modification of Diet in Renal
Disease <60 milliliter per minute (mL/min) per 1.73 meter squared (m²)

- Have a history of glaucoma

- Have a history of galactose intolerance, Lapp lactase deficiency, or glucose-galactose
malabsorption