Metabolic Impact of Time Restricted Feeding
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 8/26/2018 |
| Start Date: | September 1, 2017 |
| End Date: | June 1, 2022 |
Using Novel Digital Mobile Technology to Implement Time-restricted Feeding to Improve the Metabolic Health of Overweight and Obese Participants at Risk for Developing Diabetes
The investigators are interested in how time-restricted feeding will impact weight, sleep
duration and efficacy, and activity levels in obese adults. Significant advances in digital
mobile technology allow detailed measures of an individual's habits, permitting the
opportunity for personalized dietary and lifestyle recommendations. This is especially
relevant as time-restricted feeding appears to promote weight loss independent of calorie
intake, potentially shifting the paradigm of dietary recommendations from a calorie-based to
a time-based perspective.
duration and efficacy, and activity levels in obese adults. Significant advances in digital
mobile technology allow detailed measures of an individual's habits, permitting the
opportunity for personalized dietary and lifestyle recommendations. This is especially
relevant as time-restricted feeding appears to promote weight loss independent of calorie
intake, potentially shifting the paradigm of dietary recommendations from a calorie-based to
a time-based perspective.
Given the obesity epidemic, there is intense medical and public interest in dietary and
lifestyle management to mitigate obesity and its associated complications. Although weight
loss has traditionally focused on restricting calories, it is well described that most people
are unable to maintain the caloric restriction required to long term weight loss or
maintenance. This proposal will address whether restricting the timing of food intake, rather
than restricting calories, may facilitate weight loss and provide metabolic benefits. It has
been recently shown that the average American eats over the course of 15 hours per day. Such
an eating cycle dictates that most people are always in a fed metabolic state and likely
misaligns circadian patterns. Time-restricted feeding (TRF) is the process of limiting food
consumption to a specific window of time (e.g. 8 hours per day) and is associated with weight
loss in humans and metabolic improvements in rodent studies. Significant advances in digital
mobile technology now allow further detailed measures of an individual's habits to facilitate
this analysis. Thus, the objective of this study is to test the health related effects of 12
week TRF (8 hour fed and 16 hour fasting cycle) in overweight/obese adults. The investigators
hypothesize that TRF will 1) improve sleep duration, sleep efficacy, increase activity and
increase basal metabolic rate, 2) promote weight loss and lower body fat, and 3) improve
insulin sensitivity and postprandial hyperglycemia. The investigators expect these studies to
show that TRF is effective and sustainable approach to improving metabolic parameters in
overweight/obese individuals.
lifestyle management to mitigate obesity and its associated complications. Although weight
loss has traditionally focused on restricting calories, it is well described that most people
are unable to maintain the caloric restriction required to long term weight loss or
maintenance. This proposal will address whether restricting the timing of food intake, rather
than restricting calories, may facilitate weight loss and provide metabolic benefits. It has
been recently shown that the average American eats over the course of 15 hours per day. Such
an eating cycle dictates that most people are always in a fed metabolic state and likely
misaligns circadian patterns. Time-restricted feeding (TRF) is the process of limiting food
consumption to a specific window of time (e.g. 8 hours per day) and is associated with weight
loss in humans and metabolic improvements in rodent studies. Significant advances in digital
mobile technology now allow further detailed measures of an individual's habits to facilitate
this analysis. Thus, the objective of this study is to test the health related effects of 12
week TRF (8 hour fed and 16 hour fasting cycle) in overweight/obese adults. The investigators
hypothesize that TRF will 1) improve sleep duration, sleep efficacy, increase activity and
increase basal metabolic rate, 2) promote weight loss and lower body fat, and 3) improve
insulin sensitivity and postprandial hyperglycemia. The investigators expect these studies to
show that TRF is effective and sustainable approach to improving metabolic parameters in
overweight/obese individuals.
Inclusion Criteria:
1. Age 18-65
2. BMI ≥ 25
3. Stable sleep and work schedule
4. Owns a smart phone
5. Capable of giving informed consent
Exclusion Criteria:
1. Pregnant
2. Nursing
3. Anticipation of pregnancy during the course of the study
4. Clinically significant medical issues as determined by the study clinician
We found this trial at
1
site
Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Lisa Chow, MD
Phone: 612-625-8934
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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