Regulating Homeostatic Plasticity and the Physiological Response to rTMS
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 11/30/2018 |
| Start Date: | November 16, 2017 |
| End Date: | October 30, 2019 |
| Contact: | Mark S Mennemeier, PhD |
| Email: | msmennemeier@uams.edu |
| Phone: | 205-410-2413 |
This device-study includes a pilot, physiological investigation of normal human subjects. The
aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry
as measured by EEG recording. Currently, the application of non-invasive neuromodulation is
rarely guided by detailed knowledge of how neural activity is altered in the brain circuits
that are targeted for intervention. This gap in knowledge is problematic for interpreting
response variability, which is common. To address this gap, the current proposal aims to
combine two forms of neuromodulation sequentially, transcranial direct current stimulation
(tDCS) and repetitive transcranial magnetic stimulation (rTMS), to regulate homeostatic
plasticity prior to rTMS delivery at different frequencies of rTMS. Homeostatic plasticity,
the initial activation state of a targeted circuit, is a key determinant of whether rTMS
induces long term potentiation (LTP) or long term depression (LTD) Yet, homeostatic
plasticity is rarely measured or controlled in rTMS studies. We aim to control homeostatic
plasticity by preconditioning the targeted circuits with tDCS prior to rTMS delivery. The
protocol also includes an exploratory aim to examine physiological changes in patients with
tinnitus who only receive active stimulation, however, the exploratory aim is not part of the
pilot physiological investigation.
aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry
as measured by EEG recording. Currently, the application of non-invasive neuromodulation is
rarely guided by detailed knowledge of how neural activity is altered in the brain circuits
that are targeted for intervention. This gap in knowledge is problematic for interpreting
response variability, which is common. To address this gap, the current proposal aims to
combine two forms of neuromodulation sequentially, transcranial direct current stimulation
(tDCS) and repetitive transcranial magnetic stimulation (rTMS), to regulate homeostatic
plasticity prior to rTMS delivery at different frequencies of rTMS. Homeostatic plasticity,
the initial activation state of a targeted circuit, is a key determinant of whether rTMS
induces long term potentiation (LTP) or long term depression (LTD) Yet, homeostatic
plasticity is rarely measured or controlled in rTMS studies. We aim to control homeostatic
plasticity by preconditioning the targeted circuits with tDCS prior to rTMS delivery. The
protocol also includes an exploratory aim to examine physiological changes in patients with
tinnitus who only receive active stimulation, however, the exploratory aim is not part of the
pilot physiological investigation.
Background and Rationale: The aim of this study is to determine how existing non-invasive
neuromodulation devices affect brain physiology as measured by EEG recording. Currently, the
use of non-invasive neuromodulation is rarely guided by a detailed knowledge of how neural
activity is altered in the brain circuits that are targeted for intervention. This gap in
knowledge is problematic for interpreting response variability, which is common. To address
this gap, the current proposal aims to combine two forms of neuromodulation sequentially,
transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic
stimulation (rTMS), to regulate homeostatic plasticity prior to rTMS delivery at different
frequencies. Homeostatic plasticity, the initial activation state of a targeted circuit, is a
key determinant of whether rTMS induces long term potentiation (LTP) or long term depression
(LTD).Yet, homeostatic plasticity is rarely measured or controlled in rTMS studies. In a
physiological investigation of health subjects, we aim to control homeostatic plasticity by
preconditioning the targeted circuits with tDCS prior to rTMS delivery. The justification for
this study is that controlling homeostatic plasticity can reduce subject variability and the
knowledge gained can be used to optimize rTMS delivery. What is needed to move the field
forward is a method for combining tDCS and rTMS and for measuring neuronal responses directly
which we aim to establish in this study. The pilot study project will examine the targeted
effects of neuromodulation in normal subjects. The brain regions targeted for intervention
include auditory areas in the temporal cortex (TC) that process sounds and functionally
connected regions of the dorsolateral frontal cortex (DLFC) that mediate sensory habituation.
neuromodulation devices affect brain physiology as measured by EEG recording. Currently, the
use of non-invasive neuromodulation is rarely guided by a detailed knowledge of how neural
activity is altered in the brain circuits that are targeted for intervention. This gap in
knowledge is problematic for interpreting response variability, which is common. To address
this gap, the current proposal aims to combine two forms of neuromodulation sequentially,
transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic
stimulation (rTMS), to regulate homeostatic plasticity prior to rTMS delivery at different
frequencies. Homeostatic plasticity, the initial activation state of a targeted circuit, is a
key determinant of whether rTMS induces long term potentiation (LTP) or long term depression
(LTD).Yet, homeostatic plasticity is rarely measured or controlled in rTMS studies. In a
physiological investigation of health subjects, we aim to control homeostatic plasticity by
preconditioning the targeted circuits with tDCS prior to rTMS delivery. The justification for
this study is that controlling homeostatic plasticity can reduce subject variability and the
knowledge gained can be used to optimize rTMS delivery. What is needed to move the field
forward is a method for combining tDCS and rTMS and for measuring neuronal responses directly
which we aim to establish in this study. The pilot study project will examine the targeted
effects of neuromodulation in normal subjects. The brain regions targeted for intervention
include auditory areas in the temporal cortex (TC) that process sounds and functionally
connected regions of the dorsolateral frontal cortex (DLFC) that mediate sensory habituation.
Inclusion Criteria:
- complete the informed consent process
- men and women, age: 21-65 years
- negative pregnancy test (female subjects of childbearing age must take a pregnancy
test).
Exclusion Criteria:
- a personal or family history of epilepsy,
- severe head injury, aneurysm, stroke, previous cranial neurosurgery,
- sever or recurrent migraine headaches,
- metal implants in the head or neck, a pacemaker,
- pregnancy,
- medications that lower seizure threshold,
We found this trial at
1
site
529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
Phone: 501-526-7773
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
Click here to add this to my saved trials
