Study to Investigate the Effect of GSK1014802 on Ambulatory Blood Pressure

This study, previously posted by GlaxoSmithKline (GSK), was transitioned to Convergence
Pharmaceuticals, Ltd., which spun off from GSK. Convergence Pharmaceuticals, Ltd., has now
been acquired by Biogen.

Inclusion Criteria:

- Male or female between 18 and 65 years of age inclusive.

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests, liver
function and cardiac monitoring.

- A female subject is eligible to participate if she is of:

Non-childbearing potential Child-bearing potential and agrees to use a contraception
method.

- Male subjects must agree to use a contraception methods

- Body weight ≥ 50 kg and BMI within the range 19 - 40.0 kg/m2 (inclusive).

- Arm circumference ≥ 24 and ≤ 42 cm at mid level.

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria:

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

- A positive pre-study drug screen.

- Alcohol levels above the legal limit for driving at screening and the detection of any
alcohol within 24 h prior to the start of dosing in Treatment Periods 1 and 2.

- A positive test for HIV antibody.

- History of regular excessive alcohol consumption within 6 months of the study

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Use of prescription or non-prescription drugs, including any antihypertensive agent
including diuretics, vitamins, herbal and dietary supplements

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 90 day period.

- Pregnant females as determined by positive serum or urine hCG test at screening or
prior to dosing.

- Lactating females.

- Unwillingness or inability to follow the procedures outlined in the protocol.

- Subject is mentally or legally incapacitated.

- Subjects who work at night or whose work schedule includes rotating night time (10:00
PM to 6:00 AM) work.

- Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or
nicotine-containing products within 6 months prior to screening.

- Average daily caffeine intake equivalent to > 4 cups of coffee or > 6 cups of tea.

- Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or
pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior
to the first dose of study medication.

- Consumption of aged cheeses and meats, soy sauce and other tyramine rich sources
within 1 day prior to the baseline assessments.

- Current or past history of symptomatic orthostatic hypotension or history of
unexplained vasovagal episode(s).

- History of known or suspected seizures, including infantile febrile, unexplained
significant and recent loss of consciousness or history of significant head trauma
with loss of consciousness or a family history (first degree relative) of epilepsy or
seizures (fits).

- Any history of suicidal behaviour or suicidal ideation of type 4 or 5 on the C-SSRS
within 3 months of the screening visit.

- History or currently diagnosed sleep apnea.