Acute Kidney Injury in Patients With Sickle Cell Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Hospital, Anemia |
| Therapuetic Areas: | Hematology, Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 1 - 25 |
| Updated: | 10/27/2018 |
| Start Date: | January 1, 2017 |
| End Date: | January 2020 |
| Contact: | Jeffrey D Lebensburger, DO MSPH |
| Email: | jlebensburger@peds.uab.edu |
| Phone: | 205 638-9285 |
Patients with sickle cell disease may be at risk for acute kidney injury (AKI)during sickle
cell crisis (pain or acute chest syndrome). This study will evaluate the role of hemolysis
during SCD crisis on the development of AKI and the role for monitoring urine biomarkers
during an admission for crisis and during well clinic follow-up.
cell crisis (pain or acute chest syndrome). This study will evaluate the role of hemolysis
during SCD crisis on the development of AKI and the role for monitoring urine biomarkers
during an admission for crisis and during well clinic follow-up.
Patients admitted to the hospital for acute chest syndrome or vaso-occlusive pain events may
consent to participate in this study. Patients will consent to daily blood and urine
collection during their hospitalization and during well clinic visits.
Each AM, participants will have blood and urine collected, processed, and strored for future
analysis of hemolytic markers and biomarkers of kidney injury. Patients will also have strict
urine output recorded. Acute kidney injury (AKI) will be defined by the current KDIGO
definition based on either a rise in serum creatinine or decline in urine output. Patient
medical course will be reviewed to determine interventions and outcomes of their admission
based on the development of AKI.
consent to participate in this study. Patients will consent to daily blood and urine
collection during their hospitalization and during well clinic visits.
Each AM, participants will have blood and urine collected, processed, and strored for future
analysis of hemolytic markers and biomarkers of kidney injury. Patients will also have strict
urine output recorded. Acute kidney injury (AKI) will be defined by the current KDIGO
definition based on either a rise in serum creatinine or decline in urine output. Patient
medical course will be reviewed to determine interventions and outcomes of their admission
based on the development of AKI.
Inclusion Criteria:
- Patients with HbSS or SB0 thalassemia admitted for vaso-occlusive pain crisis or acute
chest syndrome
- Able to sign informed consent
Exclusion Criteria:
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