Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 20 - 65 |
| Updated: | 8/18/2018 |
| Start Date: | July 17, 2017 |
| End Date: | June 6, 2019 |
| Contact: | Haley L Marks, PhD |
| Email: | hmarks@mgh.harvard.edu |
| Phone: | 6176439235 |
This research study aims to determine if there are differences in oxygen consumption between
chronically sun exposed and less sun exposed skin. This study uses a new imaging device that
can detection oxygenation properties skin in a non-invasive manner.
chronically sun exposed and less sun exposed skin. This study uses a new imaging device that
can detection oxygenation properties skin in a non-invasive manner.
Sun and ultraviolet light exposure has both short term and long term effects on skin. While
the short term effects, such as sunburn, are understood, chronic long-term sun exposure can
cause changes to the skin that are not well characterized. One particular alteration may be
how the skin consumes oxygen, a change that may be linked to biochemical alterations that
have been observed in past studies. Measuring skin oxygen consumption has traditionally been
difficult as the tools available have not been easy to incorporate into clinical studies. In
this study, we overcome this barrier through the use of a new non-invasive oxygen-sensing
device that can rapidly measure skin oxygenation properties such as oxygen consumption. This
observational study will measure the oxygenation properties of both chronically sun exposed
and less sun exposed skin in the predefined groups of both young and older men and women.
the short term effects, such as sunburn, are understood, chronic long-term sun exposure can
cause changes to the skin that are not well characterized. One particular alteration may be
how the skin consumes oxygen, a change that may be linked to biochemical alterations that
have been observed in past studies. Measuring skin oxygen consumption has traditionally been
difficult as the tools available have not been easy to incorporate into clinical studies. In
this study, we overcome this barrier through the use of a new non-invasive oxygen-sensing
device that can rapidly measure skin oxygenation properties such as oxygen consumption. This
observational study will measure the oxygenation properties of both chronically sun exposed
and less sun exposed skin in the predefined groups of both young and older men and women.
Inclusion Criteria:
- Male or female
- Age groups: 20 - 30 and 55 - 65
- Fitzpatrick skin types I, II, III, and IV
Exclusion Criteria:
- Fitzpatrick skin types V and above
- Tattoo markings anywhere on the arm(s)
- Significant scarring or discoloration (e.g. birthmarks) on the arm(s)
- Any current injuries, infections or wounds on the arm(s)
- Routinely (4+ doses per week) take high dosages of anti-inflammatory drugs (e.g.
aspirin, ibuprofen, corticosteroids), immunosuppressive drugs, or antihistamine
medications. However steroid nose drops and/or eye drops are permitted.
- Has taken an anti-inflammatory drug (e.g. aspirin) within the prior 24 hours of the
study visit.
- Have diabetes that is treated with injectable or oral insulin
- Have any other active or chronic skin problems on the arms
- Are currently participating in another skin care product study at this or any other
facility
- Have participated in any type of skin product treatment study within the past 2 weeks
- Have or ever have had dermatographia
- Pregnant women
- Lactating women
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