Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 10/21/2017 |
| Start Date: | November 5, 2017 |
| End Date: | January 31, 2022 |
| Contact: | Rachel Dieterich, RN |
| Email: | rrd8w@virginia.edu |
| Phone: | 4342436074 |
Hyper polarized xenon-129 MRI (HXe MRI) is a unique imaging test which can detect how air is
flowing in and out of lungs and how oxygen can move from inhaled air into the blood. Chronic
Obstructive Pulmonary Disease (COPD) is a disease in which patients develop narrowing of
airways, thus, having difficulties breathing air in and out their lungs and also damaging the
lung tissues which patients need to move oxygen from the air into blood.
In this study, two drugs which are already approved by FDA (Anoro and Arnuity) will be
administered to patients who are already known to have COPD. While patients are being treated
with these two drugs (one drug at a time over a month), lung health by using usual testing
methods (CT scan of the lung, pulmonary function test, and blood test) will be assessed in
addition to HXe MRI.
The goal of this study is to prove that the HXe MRI is an excellent imaging test to show the
state of lung health among COPD patients and also to obtain new informations on how lung
health changes with drugs that are already approved by US FDA. This work is anticipated to
help develop HXe MRI as a new clinical test which can guide how to treat patients with COPD
and if new therapies can improve lung health of patients with COPD.
flowing in and out of lungs and how oxygen can move from inhaled air into the blood. Chronic
Obstructive Pulmonary Disease (COPD) is a disease in which patients develop narrowing of
airways, thus, having difficulties breathing air in and out their lungs and also damaging the
lung tissues which patients need to move oxygen from the air into blood.
In this study, two drugs which are already approved by FDA (Anoro and Arnuity) will be
administered to patients who are already known to have COPD. While patients are being treated
with these two drugs (one drug at a time over a month), lung health by using usual testing
methods (CT scan of the lung, pulmonary function test, and blood test) will be assessed in
addition to HXe MRI.
The goal of this study is to prove that the HXe MRI is an excellent imaging test to show the
state of lung health among COPD patients and also to obtain new informations on how lung
health changes with drugs that are already approved by US FDA. This work is anticipated to
help develop HXe MRI as a new clinical test which can guide how to treat patients with COPD
and if new therapies can improve lung health of patients with COPD.
Inclusion Criteria:
- post bronchodilator PFT spirometry FEV1/FVC < 70% predicted
- History of diagnosis of COPD
- History of alpha 1 anti-trypsin deficiency
Exclusion Criteria:
- previous diagnosis of asthma, interstitial lung disease, pulmonary vascular disease,
inability to complete MRI or any of the assessment testings.
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