Skeletal Muscle and Adipose Tissue Study



Status:Recruiting
Conditions:Orthopedic
Therapuetic Areas:Orthopedics / Podiatry
Healthy:No
Age Range:12 - 20
Updated:1/26/2019
Start Date:May 29, 2018
End Date:December 2019
Contact:Judith M. Wishin, BSN
Email:jwishin@anest.ufl.edu
Phone:352-273-9096

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Trial Summary
Trial Overview
Inclusion Criteria

Skeletal Muscle and Adipose Tissue Concentrations of Cefazolin Comparing Two Different Dosing Regimens During Pediatric Posterior Spinal Fusion Surgery

The purpose of this research study is to compare the current standard of care for
prophylactic Cefazolin administered every 3 hours intravenously with continuous infusion of
Cefazolin during pediatric spinal surgery.

Determine the skeletal muscle and adipose tissue disposition of prophylactic Cefazolin using
microdialysis sampling in a cohort of patients diagnosed with idiopathic scoliosis undergoing
posterior spinal fusion (PSF) for administration of Cefazolin by either continuous infusion
or intermittent bolus.

Inclusion Criteria:

- Diagnosis of idiopathic scoliosis

- Planned posterior spinal fusion surgery (PSFS)

- Age: 12-20 years old

- American Society of Anesthesiology status I or II undergoing posterior spinal fusion
for at least 6 levels

- No known allergy to cefazolin

Exclusion Criteria:

- Known allergy to cefazolin

- Anatomical or other abnormalities that precluded insertion of a microdialysis catheter
into the selected paraspinal muscle

- Known renal or hepatic insufficiency or failure
We found this trial at
1
site
University of Florida
Gainesville, Florida 32610
(352) 392-3261
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Gainesville, FL
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