Interactions of Environmental and Human Microbial Communities in a Pediatric Oncology Hospital
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 8/22/2018 |
| Start Date: | February 23, 2017 |
| End Date: | February 19, 2018 |
Microorganisms that colonize hospital environments play an important role in the transmission
of hospital acquired infections (HAI) and multi-drug resistant organisms. Previous studies
examining microorganisms in the hospital environment have been limited by reliance on
targeted culture-based methods resulting in potentially missed or unrecognized organisms.
Evidence now suggests that using microbiome analysis offers an innovative strategy that may
improve our understanding of HAI and how best to prevent them.
This pilot longitudinal observational study aims to characterize the taxonomic composition of
microbial communities on environmental surfaces and people in these environments prior to and
following the introduction of patients, caregiver, and hospital staff to newly constructed
inpatient care areas at St. Jude Children's Research Hospital (SJCRH). This proposed study is
uniquely characterized by evaluating the hospital environment of a pediatric
immunocompromised oncology patient population that has not been studied in the past using
advanced molecular techniques such as microbiome analysis.
PRIMARY OBJECTIVE:
- To describe the pattern of microbial communities of the hospital environment before,
during and after patient occupancy of a newly constructed hospital space.
SECONDARY OBJECTIVES:
- To describe the similarity or difference of environment microbial communities to that of
the humans occupying this environment in a newly occupied hospital space.
- To describe the pattern in environment microbial communities after each step of
disinfection (manual cleaning with chemical disinfectant and Ultraviolet light
disinfection machine) after patient discharge from the inpatient hospital environment.
- To evaluate the correlation between environmental Adenosine Triphosphate (ATP) measures
and organism bioburden.
of hospital acquired infections (HAI) and multi-drug resistant organisms. Previous studies
examining microorganisms in the hospital environment have been limited by reliance on
targeted culture-based methods resulting in potentially missed or unrecognized organisms.
Evidence now suggests that using microbiome analysis offers an innovative strategy that may
improve our understanding of HAI and how best to prevent them.
This pilot longitudinal observational study aims to characterize the taxonomic composition of
microbial communities on environmental surfaces and people in these environments prior to and
following the introduction of patients, caregiver, and hospital staff to newly constructed
inpatient care areas at St. Jude Children's Research Hospital (SJCRH). This proposed study is
uniquely characterized by evaluating the hospital environment of a pediatric
immunocompromised oncology patient population that has not been studied in the past using
advanced molecular techniques such as microbiome analysis.
PRIMARY OBJECTIVE:
- To describe the pattern of microbial communities of the hospital environment before,
during and after patient occupancy of a newly constructed hospital space.
SECONDARY OBJECTIVES:
- To describe the similarity or difference of environment microbial communities to that of
the humans occupying this environment in a newly occupied hospital space.
- To describe the pattern in environment microbial communities after each step of
disinfection (manual cleaning with chemical disinfectant and Ultraviolet light
disinfection machine) after patient discharge from the inpatient hospital environment.
- To evaluate the correlation between environmental Adenosine Triphosphate (ATP) measures
and organism bioburden.
Participants will be recruited from the patient population at SJCRH. Patients admitted to one
of the protocol defined inpatient rooms in the Kay Research and Care Center (KRCC) will be
enrolled on the study. Participating patients will be asked to provide stool, nasal swab, and
skin swab samples while inpatient. Primary caregivers and the nurse assigned to the patient's
room will also be asked to provide nasal and skin swabs while the patient remains inpatient.
These samples will be used to characterize the human microbiome for comparison to the
environmental microbiome.
of the protocol defined inpatient rooms in the Kay Research and Care Center (KRCC) will be
enrolled on the study. Participating patients will be asked to provide stool, nasal swab, and
skin swab samples while inpatient. Primary caregivers and the nurse assigned to the patient's
room will also be asked to provide nasal and skin swabs while the patient remains inpatient.
These samples will be used to characterize the human microbiome for comparison to the
environmental microbiome.
Patient Participant Inclusion Criteria:
- Patients scheduled to be admitted or admitted to SJCRH,
- Admitted to one of the protocol defined inpatient rooms in the KRCC building at SJCRH,
- Patient, parents or legal guardian willing and able to provide informed consent and
comply with study requirements,
- When applicable, participant is willing to provide assent and comply with the study
requirements.
Patient Participant Exclusion Criteria:
- Inability or unwillingness of participant or legal guardian/representative to give
written informed consent.
Primary Caregiver Participant Inclusion Criteria
- Primary caregiver anticipated to provide care for patient while he or she is inpatient
at St. Jude Children's Research Hospital,
- ≥ 18 years old,
- Able and willing to provide informed consent and comply with study requirements.
Primary Caregiver Participant Exclusion Criteria
- Inability or unwillingness of primary caregiver to give informed consent.
- Primary Nurse Participant Inclusion Criteria
- Nurse assigned to patient participant on the day of patient participant sample
collection
- Willing to provide informed consent
Primary Nurse Participant Exclusion Criteria
- Inability or unwillingness to provide informed consent
We found this trial at
1
site
262 Danny Thomas Pl
Memphis, Tennessee 38105
Memphis, Tennessee 38105
(901) 495-3300
Principal Investigator: Hana Hakim, MD
Phone: 866-278-5833
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
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