SI + CC Versus 3:1 C:V Ratio During Neonatal CPR

Status:	Recruiting
Conditions:	Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	Any
Updated:	4/6/2019
Start Date:	October 19, 2017
End Date:	August 2021
Contact:	Georg Schmolzer
Email:	georg.schmoelzer@me.com
Phone:	+1 7807354647

SURV1VE-Trial - Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns: A Randomized Controlled Trial

Research question In newborn infants requiring CPR, does CC superimposed by sustained
inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous
circulation?

Overall objective: CC superimposed by sustained inflation will improve short- and long-term
outcomes in preterm (>28 weeks or older) and term newborns.

Hypothesis to be tested Primary hypothesis: By using CC superimposed by sustained inflation
(CC+SI) during CPR the time needed to achieve return of spontaneous circulation (ROSC)
compared to the current 3:1 compression to ventilation (C:V) will be reduced in asphyxiated
newborns.

Inclusion Criteria:

- Infants (term or preterm infants >28 weeks' gestation) requiring CC in the delivery
room will be eligible for the trial.

Exclusion Criteria:

- Infants will be excluded if they have a congenital abnormality or condition that might
have an adverse effect on breathing or ventilation (e.g. congenital diaphragmatic
hernia), or congenital heart disease requiring intervention in the neonatal period.
Infants would be also excluded if their parents refused to give consent to this study.

We found this trial at

sites

Royal Women's Hospital

Melbourne,

Principal Investigator: Omar Kamlin

from

Melbourne,