SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/6/2019 |
| Start Date: | October 19, 2017 |
| End Date: | August 2021 |
| Contact: | Georg Schmolzer |
| Email: | georg.schmoelzer@me.com |
| Phone: | +1 7807354647 |
SURV1VE-Trial - Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns: A Randomized Controlled Trial
Research question In newborn infants requiring CPR, does CC superimposed by sustained
inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous
circulation?
Overall objective: CC superimposed by sustained inflation will improve short- and long-term
outcomes in preterm (>28 weeks or older) and term newborns.
Hypothesis to be tested Primary hypothesis: By using CC superimposed by sustained inflation
(CC+SI) during CPR the time needed to achieve return of spontaneous circulation (ROSC)
compared to the current 3:1 compression to ventilation (C:V) will be reduced in asphyxiated
newborns.
inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous
circulation?
Overall objective: CC superimposed by sustained inflation will improve short- and long-term
outcomes in preterm (>28 weeks or older) and term newborns.
Hypothesis to be tested Primary hypothesis: By using CC superimposed by sustained inflation
(CC+SI) during CPR the time needed to achieve return of spontaneous circulation (ROSC)
compared to the current 3:1 compression to ventilation (C:V) will be reduced in asphyxiated
newborns.
Inclusion Criteria:
- Infants (term or preterm infants >28 weeks' gestation) requiring CC in the delivery
room will be eligible for the trial.
Exclusion Criteria:
- Infants will be excluded if they have a congenital abnormality or condition that might
have an adverse effect on breathing or ventilation (e.g. congenital diaphragmatic
hernia), or congenital heart disease requiring intervention in the neonatal period.
Infants would be also excluded if their parents refused to give consent to this study.
We found this trial at
3
sites
3003 Health Center Drive
San Diego, California 92123
San Diego, California 92123
Principal Investigator: Anup Katheria
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Tucson, Arizona 85724
Principal Investigator: Ranjit Kylathu
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