Neostigmine For Snoring During DISE
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/22/2018 |
| Start Date: | November 14, 2017 |
| End Date: | August 2019 |
| Contact: | Raj C. Dedhia, MD MS |
| Email: | raj.dedhia@emory.edu |
| Phone: | 404-778-3015 |
Local Neostigmine for Treatment of Snoring During Drug-Induced Sleep Endoscopy
The study team is seeking a novel treatment for snoring involving local application of a
nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5
sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to
evaluate the effect on snoring.
nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5
sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to
evaluate the effect on snoring.
Snoring is a major problem, affecting 40 million Americans. The disease affects patient and
partner sleep quality as well as daytime function. Snoring treatment is limited by device
compliance (mouth appliance, positive airway pressure) and insurance does not regularly pay
for these devices. Surgical treatment for snoring has mixed results. As a result, there is an
important need to develop new treatments for snoring.
The study team is seeking a novel treatment for snoring involving local application of a
nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5
sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to
evaluate the effect on snoring. If successful, development of a topical (non-injectable)
version of this drug will be considered, so that the patient can apply him/herself before
bedtime.
partner sleep quality as well as daytime function. Snoring treatment is limited by device
compliance (mouth appliance, positive airway pressure) and insurance does not regularly pay
for these devices. Surgical treatment for snoring has mixed results. As a result, there is an
important need to develop new treatments for snoring.
The study team is seeking a novel treatment for snoring involving local application of a
nerve stimulant medication, neostigmine. In this study, neostigmine will be injected into 5
sites of the soft palate during a standard procedure, drug-induced sleep endoscopy, to
evaluate the effect on snoring. If successful, development of a topical (non-injectable)
version of this drug will be considered, so that the patient can apply him/herself before
bedtime.
Inclusion Criteria:
- Snoring or mild obstructive sleep apnea
- English-speaking
- Greater than 18 years old
- Able to give informed consent
Exclusion Criteria:
- On active anti-coagulation medication
- Pregnant women
- Hypersensitivity to neostigmine
- Peritonitis or mechanical obstruction of the intestinal or urinary tract
- Coronary artery disease
- Cardiac arrhythmia
- Recent acute coronary syndrome
- Myasthenia gravis
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