Study of Ocular Penetration of Topically Administered Fluoroquinolones

Inclusion Criteria:

- Subjects who have a visually significant cataract and are planning to have cataract
surgery.

- Subjects who are willing/able and have signed informed consent approved by the
Institutional Review Board.

Exclusion Criteria:

- Subjects who have a known hypersensitivity, allergy, or contraindication to any
fluoroquinolone medication, in any form.

- Subjects who signs of ocular infection or active inflammation in the study eye.

- Subjects who have corneal pathology, including epithelial defect, corneal scarring, or
severe dry eye syndrome.

- Subjects who have used any disallowed medication (including antibiotics) during the
time period designated as described in the protocol.

- Subjects who have any active or chronic/recurrent ocular or systemic disease that is
uncontrolled and is likely to increase the risk of infection to the patient or
confound the results of the study.

- Subjects who are pregnant (or suspect to be pregnant) or nursing/lactating.

- Subjects who have participated in any study of an investigational drug or device
within 30 days prior to enrollment.