Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor

Inclusion Criteria:

- Be healthy

- Have a BMI of 18 to 32 kg/m2, inclusive and body weight more than 50 kg (110 pounds)

- Be judged to be in good health, based on the results of medical history, physical
examination, vital signs, 12-lead ECG, and clinical laboratory findings

- Have suitable veins for multiple venipuncture/cannulation

Exclusion Criteria:

- Have multiple drug allergies, or be allergic to any of the components of mifepristone
or itraconazole

- Have a condition that could be aggravated by glucocorticoid blockade (eg, asthma, any
chronic inflammatory condition)

- In the 1 year before study drug administration, have a history of drug or alcohol
abuse

- In the 6 calendar months before study drug administration, on average

- Have smoked more than 5 cigarettes/day

- Have consumed more than 21 units of alcohol/week (1 unit/drink = 5 ounces of
wine, or 12 ounces of beer, or 1.5 ounces of hard liquor)

- In 2 months prior to study drug administration, have donated/lost blood or plasma in
excess of 400 mL

- In the 30 days before study drug administration, have participated in another clinical
trial of a new chemical entity or a prescription medicine