Transcranial Magnetic Stimulation in Stroke Motor Rehabilitation Treatment
| Status: | Withdrawn |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 30 - 80 |
| Updated: | 4/17/2018 |
| Start Date: | March 2018 |
| End Date: | June 28, 2019 |
Targeting Motor Areas for Customized Transcranial Magnetic Stimulation in Motor Rehabilitation Treatment of Chronic Stroke Patients
The goal of the study is to determine the effect of repetitive transcranial magnetic
stimulation (rTMS) over the premotor cortex on training-related improvements in motor
performance and associated neural plasticity.
stimulation (rTMS) over the premotor cortex on training-related improvements in motor
performance and associated neural plasticity.
Occlusion of the middle cerebral artery is the most common cause of stroke. Because the
middle cerebral artery supplies blood to the motor cortices, middle cerebral artery stroke
often impacts the integrity of the motor cortex and its associated corticospinal projections.
Less than half of all individuals post-stroke regain complete motor function. Because motor
deficits, especially of the upper extremities, can dampen the quality of life, there is an
urgent need to improve current rehabilitation programs to allow more stroke survivors to
achieve higher functional gains.
Motor training is an important part of recovery after stroke. During motor training, patients
practice performing a movement and become better at performing the trained movement over
time. Repetitive transcranial magnetic stimulation (rTMS), which uses magnetism to excite
neurons near the surface of the brain, may further improve performance. There is evidence
that the premotor cortex may be a more effective target than the primary motor cortex for
rTMS for some stroke survivors. In the current study, the investigator will determine the
effect of rTMS over the premotor cortex on training-related improvements in motor performance
in adults who experienced a stroke more than 6 months ago.
middle cerebral artery supplies blood to the motor cortices, middle cerebral artery stroke
often impacts the integrity of the motor cortex and its associated corticospinal projections.
Less than half of all individuals post-stroke regain complete motor function. Because motor
deficits, especially of the upper extremities, can dampen the quality of life, there is an
urgent need to improve current rehabilitation programs to allow more stroke survivors to
achieve higher functional gains.
Motor training is an important part of recovery after stroke. During motor training, patients
practice performing a movement and become better at performing the trained movement over
time. Repetitive transcranial magnetic stimulation (rTMS), which uses magnetism to excite
neurons near the surface of the brain, may further improve performance. There is evidence
that the premotor cortex may be a more effective target than the primary motor cortex for
rTMS for some stroke survivors. In the current study, the investigator will determine the
effect of rTMS over the premotor cortex on training-related improvements in motor performance
in adults who experienced a stroke more than 6 months ago.
Inclusion Criteria:
- Have the ability to give informed, written consent
- Be aged 30-80 years old
- Have a single ischemic infarction affecting the primary motor system
- Have intact cognitive abilities
- No current depression
- No neurological disease
- No contradictions to TMS
- No history of seizures or epilepsy
- No implanted medical device
- No metal in neck or head
- No history of migraine headaches
- No intake of medication that lowers seizure threshold
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