Diuretic/Cool Dialysate Trial

This pilot/feasibility RCT will recruit for 18 months and demonstrate the feasibility and
safety of performing a large scale study of diuretic use and/or cool dialysate examining
recruitment, retention, and key outcomes. This study will further assess whether the use of a
diuretic compared to non-use of a diuretic and/or the use of cool dialysate (35.5 ºC)
compared to 37 ºC for up to 6 months will improve residual renal function (RRF), improve
health reported quality of life (HRQOL) and reduce hospitalizations by randomizing 20
dialysis-naïve patients (started chronic HD in the last three months) from DCI centers in the
greater Albuquerque area, to either bumetanide and cool dialysate randomized in a two-by-two
factorial distribution.

Inclusion Criteria:

- Primary speaking language is English.

- Patient is HD naïve (Patient may still enroll as long as no more than 12 weeks of
in-center HD have been performed prior to randomization)

- HD takes place at one of the participating Dialysis Clinic Inc. (DCI) sites during the
data collection period.

- Daily urine output is over 500ml.

- Patients must be willing and able to sign the consent form.

Exclusion Criteria:

- RRF <5 mL/min/1.73 m2 as determined by iohexol GFR measurement.

- Allergy or contraindication to iohexol and/or bumetanide.

- Has been undergoing dialysis for more than 12 weeks.

- Expectation that native kidneys will recover.

- History of poor adherence to treatment.

- Unable to verbally communicate in English.

- Requires more than 3 HD treatments per week due to medical co-morbidity (such as, but
not limited to: severe volume overload requiring frequent HD e.g. in systemic
oxalosis, or requiring total parenteral nutrition).

- Scheduled for living donor kidney transplant in the next 6 months.

- Intention to change to peritoneal dialysis, or home HD in the next 6 months.

- Plan to relocate to another center within the next 7-8 months.

- Expected geographic unavailability at a participating HD unit for >2 consecutive weeks
or >4 weeks total during the next 6 months (excluding unavailability due to
hospitalizations)

- Post kidney transplantation

- Currently in an acute or chronic care hospital

- Life expectancy <6 months or intention to withdraw dialysis therapy within 6 months.

- Current pregnancy

- Actively planning to become pregnant in the next 8 months

- Nursing mothers

- Current use of investigational drugs

- Participation in another non-observational clinical trial that contradicts or
interferes with the therapies or measured outcomes in this trial

- Unable or unwilling to follow the study protocol for any reason (including mental
incompetence)

- Unable or unwilling to provide informed consent or sign IRB-approved consent form.

The following special populations will not be included in this study:

- Patients who are too infirm or lack the capacity to meaningfully participate in
medical decisions and to sign the informed consent.

- Children and adolescents constitute <2% of the dialysis population, and our
preliminary survey of the study sites found no children and adolescents were active
patients. In any case, the renal and other physical factors of children and
adolescents with ESRD are not directly comparable to those of adults.

- Prisoners.