Effect of Lap-Band Induced Weight Loss on Serum PSA Levels
| Status: | Withdrawn |
|---|---|
| Conditions: | Prostate Cancer, Cancer, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology, Oncology |
| Healthy: | No |
| Age Range: | 20 - 60 |
| Updated: | 8/25/2018 |
| Start Date: | November 2007 |
| End Date: | December 31, 2009 |
Effect of Lap-Band Induced Weight Loss on Serum PSA Levels, Testosterone, Estrogen and Other Serum Markers
The proposed prospective study aims to determine whether interpretation of PSA levels in
morbidly obese men require correction due to the obesity itself. If PSA levels are found to
rise after weight loss, interpretation of PSA levels in morbidly obese men may be improved by
upward correction of the PSA level. A 'correction factor' may be proposed for the
interpretation of PSA levels in obese men, toward the clinical decision regarding indication
for prostate biopsy.
morbidly obese men require correction due to the obesity itself. If PSA levels are found to
rise after weight loss, interpretation of PSA levels in morbidly obese men may be improved by
upward correction of the PSA level. A 'correction factor' may be proposed for the
interpretation of PSA levels in obese men, toward the clinical decision regarding indication
for prostate biopsy.
The main objective of this study is to determine whether interpretation of PSA levels in
morbidly obese men require correction due to the obesity itself. Secondary outcome measures
that will be followed include the affect of obesity and weight loss on testosterone,
estradiol and leptin. In as much as these might also affect PSA, we will be measuring these
values as well. Also, we do not know the effects of lap-band induced weight loss on clinical
outcome measures of sexual, bowel and urinary function. Thus we will aim to investigate these
parameters as well.
morbidly obese men require correction due to the obesity itself. Secondary outcome measures
that will be followed include the affect of obesity and weight loss on testosterone,
estradiol and leptin. In as much as these might also affect PSA, we will be measuring these
values as well. Also, we do not know the effects of lap-band induced weight loss on clinical
outcome measures of sexual, bowel and urinary function. Thus we will aim to investigate these
parameters as well.
Inclusion Criteria:
- obese men undergoing lap-band surgery
Exclusion Criteria:
- prior diagnosis of prostate cancer
- prior prostate surgery
- use of 5-alpha reductase inhibitors
- history of prostatitis
- recurrent Urinary Tract Infection (UTI).
We found this trial at
1
site
Maimonides Medical Center At 103 years old, Maimonides Medical Center remains a vital and thriving...
Click here to add this to my saved trials
