Non-Contrast Enhanced Peripheral Magnetic Resonance Angiography
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/28/2017 |
| Start Date: | April 2008 |
| End Date: | June 2018 |
To systematically develop, test, and refine peripheral vascular electrocardiography-gated
fast spin echo magnetic resonance imaging for the accurate diagnosis of peripheral arterial
disease without gadolinium contrast.
To test prospectively the accuracy of fast spin echo in peripheral arterial disease patients,
compared with bolus-chase and time-resolved gadolinium enhanced magnetic resonance
angiography. Additionally, as a substudy of this project, we will compare our fast spin echo
approach with alternative non-contrast-enhanced magnetic resonance imaging methods such as
time-of-flight and steady-state gradient echo imaging.
The overarching goals of our research are to develop and validate a peripheral magnetic
resonance imaging technique that accurately depicts anatomy and disease without exposing
patients to exogenous contrast material and its associated risks.
fast spin echo magnetic resonance imaging for the accurate diagnosis of peripheral arterial
disease without gadolinium contrast.
To test prospectively the accuracy of fast spin echo in peripheral arterial disease patients,
compared with bolus-chase and time-resolved gadolinium enhanced magnetic resonance
angiography. Additionally, as a substudy of this project, we will compare our fast spin echo
approach with alternative non-contrast-enhanced magnetic resonance imaging methods such as
time-of-flight and steady-state gradient echo imaging.
The overarching goals of our research are to develop and validate a peripheral magnetic
resonance imaging technique that accurately depicts anatomy and disease without exposing
patients to exogenous contrast material and its associated risks.
Inclusion Criteria:
- Patients with known or suspected periphery arterial disease will be recruited.
- In the initial sequence optimization stage, healthy volunteers will also be recruited
for magnetic resonance angiography
Exclusion Criteria:
- Patients with moderate to end stage renal disease (estimated glomerular filtration
rate < 30 ml/min/1.73m2). These patients will not be recruited as they will be
unlikely to undergo routine contrast enhanced magnetic resonance angiography due to
the risk of developing Nephrogenic Systemic Fibrosis.
- Pregnant patients. Gadolinium chelates are a FDA Category C drug, and therefore should
be avoided in pregnancy.
- Claustrophobic healthy volunteers or any subject who is unable to lie flat for 60
minutes.
- Glomerular filtration rate < 60ml/min/1.72m2 and coexisting history of pro
inflammatory conditions such as recent surgery, sepsis or major infection, arterial or
venous thrombosis.
- Any history of nephrogenic systemic fibrosis
- Unable/ unwilling to give informed consent
- Medical contra-indications to magnetic resonance imaging: e.g. pacemakers, implanted
defibrillators, cochlear implants, aneurysm clips, and prior/ current metal workers.
Patients will be screened with a safety questionnaire.
- Clinically unstable patients
- Patients with newly placed stents will be excluded until 8 weeks post placement
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