Improving Pulmonary Function Following Radiation Therapy

Inclusion Criteria:

- Histologic diagnosis of non-small cell lung cancer or lung metastasis from a solid
tumor. One biopsy site is adequate for multiple sites of thoracic disease.

- Treatment includes localized radiation therapy with or without chemotherapy

- Karnofsky ≥ 60%

- Not pregnant per radiation oncology standard procedures

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Prior (within last 6 months) or future planned therapeutic surgery for the treatment
of the existing lung cancer

- Prior thoracic radiotherapy

- Severe COPD defined as disease requiring an inpatient stay for respiratory
deterioration within the past 3 months

- Oxygen dependence of > 2 L/min continuously throughout the day at baseline

- Known underlying collagen vascular disease or intrinsic lung disease that could
complicate expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's
granulomatosis)

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.