VCRC Tissue Repository

Status:	Recruiting
Conditions:	Cardiology, Cardiology, Cardiology, Cardiology, Cardiology, Hematology
Therapuetic Areas:	Cardiology / Vascular Diseases, Hematology
Healthy:	No
Age Range:	Any
Updated:	3/27/2019
Start Date:	November 2016
End Date:	December 2019
Contact:	Sherry Xu
Email:	sherryxu@pennmedicine.upenn.edu

VCRC Tissue Biorepository Collection Protocol

The purpose of this study is to collect existing tissue specimens from subjects enrolled in
Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens
and linked clinical data collected through VCRC studies may lead to the identification and
development of a series of translational research projects. Results of these studies will
provide vasculitis researchers with insight into the causes of these diseases and generate
new ideas for diagnostic tests and therapies, and will be of great interest to the larger
communities of researchers investigating vasculitis and other autoimmune, inflammatory, and
vascular diseases.

Biopsy specimens collected as standard of care for these diseases will be retrieved and used
in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels;
however, other tissue is also of interest for the study. Biopsies are not performed as part
of this protocol, rather we will request consent to collect biopsy specimens already
collected under routine care.

Inclusion Criteria:

- A participant will be deemed eligible for this study if the participant is/was
enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503,
5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522,
5523, 5526, 5527, or 5562).

Exclusion Criteria:

- Inability to give informed consent (or their guardians in the case of children) and to
sign the consent form.

- Unwilling to allow the use of their tissue for research.

We found this trial at

sites

St. Joseph's Healthcare

Hamilton, Ontario

from

Hamilton,