Doppler Flow Wires in Cerebral Angiography
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/1/2019 |
| Start Date: | September 1, 2019 |
| End Date: | September 1, 2019 |
| Contact: | Cory Kelly, BS |
| Email: | kellycm@neurosurgery.washington.edu |
| Phone: | 206-685-4043 |
Predicting Cerebral Aneurysm Recurrence Using Doppler Guidewire Measurements
The purpose of this study is to use a wire with a Doppler tip to measure blood flow in
vessels in the brain and determine hemodynamic factors associated with treatment success or
failure. Many neurological diseases cause abnormal blood flow in the brain in specific
vessels. The special wire used in this study is place into brain blood vessels during
standard of care procedure to treat such diseases, and blood flow parameters (such as
velocity and pressure) are measured to gain better understanding of these neurological
diseases.
vessels in the brain and determine hemodynamic factors associated with treatment success or
failure. Many neurological diseases cause abnormal blood flow in the brain in specific
vessels. The special wire used in this study is place into brain blood vessels during
standard of care procedure to treat such diseases, and blood flow parameters (such as
velocity and pressure) are measured to gain better understanding of these neurological
diseases.
Current treatments of cerebral aneurysms are imperfect, and aneurysmal hemodynamics is an
important factor in treatment failure. The identification of hemodynamic factors that
influence treatment success could predict outcome. Published studies show that the
hemodynamic environment of aneurysms changes after treatment, and there is limited
retrospective evidence that the degree of change affects treatment success. However, previous
hemodynamic calculations did not have access to patient-specific measurements of blood flow,
which substantially reduced their accuracy. In addition, no prospective studies of the
predictive value of post-treatment aneurysm hemodynamics have been done.
Methods: Prospectively test new aneurysm patients for hemodynamic predictors of treatment
outcome based upon the hypothesis long-term aneurysm treatment outcome can be prospectively
predicted by measuring the immediate hemodynamic effects of aneurysm treatment with novel
patient-specific modeling techniques. Task 1: In a new cohort of patients undergoing aneurysm
treatment, the investigators will again use Doppler guidewire measurements to create
patient-specific hemodynamic models of treatment effects. By prospectively applying the
knowledge of crucial hemodynamic changes the investigators will use immediate post-treatment
hemodynamics to predict long-term treatment outcome.
important factor in treatment failure. The identification of hemodynamic factors that
influence treatment success could predict outcome. Published studies show that the
hemodynamic environment of aneurysms changes after treatment, and there is limited
retrospective evidence that the degree of change affects treatment success. However, previous
hemodynamic calculations did not have access to patient-specific measurements of blood flow,
which substantially reduced their accuracy. In addition, no prospective studies of the
predictive value of post-treatment aneurysm hemodynamics have been done.
Methods: Prospectively test new aneurysm patients for hemodynamic predictors of treatment
outcome based upon the hypothesis long-term aneurysm treatment outcome can be prospectively
predicted by measuring the immediate hemodynamic effects of aneurysm treatment with novel
patient-specific modeling techniques. Task 1: In a new cohort of patients undergoing aneurysm
treatment, the investigators will again use Doppler guidewire measurements to create
patient-specific hemodynamic models of treatment effects. By prospectively applying the
knowledge of crucial hemodynamic changes the investigators will use immediate post-treatment
hemodynamics to predict long-term treatment outcome.
Inclusion Criteria:
- Patient with an unruptured intracranial aneurysm ≥ 5mm in size undergoes endovascular
treatment and subsequent angiographic follow-up
Exclusion Criteria:
-previously enrolled in the study
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