Evaluation of the Protection Activity of Microfine Titanium Dioxide (Ti02), Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With Idiopathic Solar Urticaria (SU)

Inclusion Criteria:

- Male or female voluntary patients at least 18 years old

- For female patients with child-bearing potential, negative pregnancy test at baseline

- Patients with a clinical and photobiological diagnosis of idiopathic SU

- Patients with no underlying condition, or with underlying conditions provided that
these conditions are stable and under control

- Patients able to follow instructions

- Written informed consent from the patients

Exclusion Criteria:

- Children (less than 18 years old)

- Pregnant or lactating women

- Women with a positive pregnancy test at baseline

- Patients with spontaneous occurrence of SU lesions on the back within 3 days prior to
study entry

- Patients with a known allergy to one of the ingredients contained in the test products

- Patients who have applied EP to back skin over the previous 2 weeks before study entry

- Patients who have applied topical corticosteroids to back skin within 7 days prior to
study entry

- Patients who have applied an emollient including white soft paraffin on back skin
within 2 days prior to study entry

- Patients with systemic exposure to corticosteroids, anti-inflammatories or other
immunosuppressive agents within the last 4 weeks prior to study entry

- Patients with oral antihistamines within the last 2 days prior to study entry

- Patients who have been administered systemic or topical photoactive medications for
phototherapy or phototherapy alone within 1 week prior to study entry

- Patients with an unstable or non-controlled underlying condition

- Patients who are not able to follow instructions

- Patients who have participated in a study within the 3 months prior to study entry

- Patients who refuse to give written informed consent