Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
| Status: | Recruiting |
|---|---|
| Conditions: | Cognitive Studies, Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 1/6/2019 |
| Start Date: | March 7, 2018 |
| End Date: | December 2019 |
| Contact: | Nicola Haakonsen |
| Email: | Nicola.Haakonsen@ucdenver.edu |
| Phone: | 303-724-4644 |
Loss of slow wave sleep (SWS) is common in mild cognitive impairment (MCI) and Alzheimer's
disease, and is thought to worsen thinking, memory and brain degeneration. Initial studies
suggest that correction of sleep deterioration may slow the progression of brain damage in
mild cognitive impairment, and might be able to stop the development of Alzheimer's disease.
Transcranial alternating current stimulation (tACS) uses electrodes to deliver very small
amounts of electricity through the brain, with direct effects on brain cell function.
Transcranial electric stimulation has been demonstrated to enhance slow wave sleep and to
improve memory when applied during sleep in healthy adults. The purpose of this research is
to investigate tACS to modulate sleep, thinking/memory, mood, and quality of life among
normal healthy adults, older adults, as well as individuals with MCI.
disease, and is thought to worsen thinking, memory and brain degeneration. Initial studies
suggest that correction of sleep deterioration may slow the progression of brain damage in
mild cognitive impairment, and might be able to stop the development of Alzheimer's disease.
Transcranial alternating current stimulation (tACS) uses electrodes to deliver very small
amounts of electricity through the brain, with direct effects on brain cell function.
Transcranial electric stimulation has been demonstrated to enhance slow wave sleep and to
improve memory when applied during sleep in healthy adults. The purpose of this research is
to investigate tACS to modulate sleep, thinking/memory, mood, and quality of life among
normal healthy adults, older adults, as well as individuals with MCI.
Inclusion Criteria:
- Ages 18-80
- Native English speakers
- Neurological diagnosis of amnestic mild cognitive impairment (aMCI)
Exclusion Criteria:
- brain tumors
- skull defects
- epilepsy
- metal implants/devices above the neck
- eczema or sensitive skin
- insomnia
- sleep apnea
- rapid eye movement (REM)-sleep behavior disorder
- narcolepsy
- restless legs syndrome
- currently pregnant or trying to become pregnant during the study period
- diagnosis of cognitive impairment *cognitive impairment required for MCI arms
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