Ultrasound Assessment of BC in the NICU
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | Any |
| Updated: | 3/23/2019 |
| Start Date: | October 23, 2017 |
| End Date: | December 31, 2019 |
| Contact: | Emily Nagel, MS |
| Email: | nagel127@umn.edu |
| Phone: | 6126243747 |
Use of Bedside Ultrasound to Assess Neonatal Body Composition in the Neonatal Intensive Care Unit
The overall objective of the proposal is to evaluate the ability of ultrasound to predict and
routinely (weekly) monitor changes in the body composition of healthy preterm infants in the
neonatal intensive care unit (NICU) in response to nutritional intake. The investigators
hypothesize that ultrasound is an accurate method to routinely monitor the quality of weight
gain and assess the adequacy of nutritional provision for premature infants in the neonatal
intensive care unit.
The investigators will address the hypothesis in the following Specific Aims:
Specific Aim 1: Validate ultrasound as a method to measure whole body fat mass and fat free
mass in healthy, premature infants. Body composition will be assessed using ultrasound
measurements and the validated method of air displacement plethysmography (ADP). Stable
isotope dilution techniques will be used in a subset of our population as a secondary source
of validation.
Specific Aim 2: Determine whether ultrasound measurements can detect clinically relevant
(weekly) changes in body composition in healthy premature infants. Ultrasound will be used to
obtain serial (weekly) measurements of muscle and adipose tissue thickness (triceps, abdomen,
quadriceps) until discharge in healthy, premature infants.
routinely (weekly) monitor changes in the body composition of healthy preterm infants in the
neonatal intensive care unit (NICU) in response to nutritional intake. The investigators
hypothesize that ultrasound is an accurate method to routinely monitor the quality of weight
gain and assess the adequacy of nutritional provision for premature infants in the neonatal
intensive care unit.
The investigators will address the hypothesis in the following Specific Aims:
Specific Aim 1: Validate ultrasound as a method to measure whole body fat mass and fat free
mass in healthy, premature infants. Body composition will be assessed using ultrasound
measurements and the validated method of air displacement plethysmography (ADP). Stable
isotope dilution techniques will be used in a subset of our population as a secondary source
of validation.
Specific Aim 2: Determine whether ultrasound measurements can detect clinically relevant
(weekly) changes in body composition in healthy premature infants. Ultrasound will be used to
obtain serial (weekly) measurements of muscle and adipose tissue thickness (triceps, abdomen,
quadriceps) until discharge in healthy, premature infants.
Inclusion Criteria:
- Healthy, premature infants 30-34 weeks gestational age at birth
- Admitted to the University of Minnesota Masonic Children's Hospital NICU
- Stable on room air or can be removed from respiratory support for 5 minutes
- Written or verbal (telephone) informed consent can be secured from a parent within 1
week of admission to the NICU
Exclusion Criteria:
-Require medical support preventing ADP measurements
We found this trial at
1
site
2450 Riverside Avenue
Minneapolis, Minnesota 55454
Minneapolis, Minnesota 55454
Phone: 231-670-7760
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