Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Hospital |
| Therapuetic Areas: | Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | Any - 8 |
| Updated: | 11/17/2018 |
| Start Date: | October 25, 2017 |
| End Date: | August 1, 2019 |
| Contact: | Douglas Atkinson, MD |
| Email: | Douglas.Atkinson@childrens.harvard.edu |
| Phone: | 617-355-6225 |
Acute kidney injury (AKI) is common in children after cardiac surgery with a reported
incidence of 20-40%. Pediatric AKI has been found to be associated with important short and
long-term adverse outcomes.
A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is
the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies
exclusively on elevation of serum creatinine concentration and oliguria. Both of these
markers lack sensitivity and specificity, and result in delayed detection of kidney injury.
This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect
subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary
bypass.
incidence of 20-40%. Pediatric AKI has been found to be associated with important short and
long-term adverse outcomes.
A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is
the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies
exclusively on elevation of serum creatinine concentration and oliguria. Both of these
markers lack sensitivity and specificity, and result in delayed detection of kidney injury.
This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect
subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary
bypass.
Inclusion Criteria:
- less than or equal to 8 years of age
- scheduled for cardiac surgery
Exclusion Criteria:
- severe pre-existing renal insufficiency
We found this trial at
1
site
300 Longwood Ave
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 355-6000
Phone: 617-355-6225
Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
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