Cognitive Remediation Therapy for Brain Tumor Patients: Improving Working Memory

Participants will be recruited by their neuropsychologist in the VCU Massey Cancer Center
following standard neuropsychological evaluation (their neuro-oncologist may refer them to
this study). If meeting inclusion criteria (described in later sections on participants),
participants will be recruited and enrolled in the study. Two groups will be formed: High
grade gliomas (WHO grade III or IV; n=15) and Low grade gliomas (WHO grade II; n=15).
Participants will be followed over 11 months. The two groups will follow identical study
timelines.

Inclusion Criteria:

- Confirmed primary brain tumor diagnosis via MRI and their neuro-oncologist

- A minimum of 2 months post-surgical resection or biopsy(if applicable)

- and/or a minimum 1 month post radiation treatment (if applicable)

- Karnofsky performance status more than 60

- Estimated intelligence at least 80 (standard score)

- Demonstrated attention difficulties (T-score of at least 65 on attention questionnaire
or 1 or more standard deviations below mean on direct attention measures)

- No history of cognitive disorder

- No history of mood disorder

- Predicted life expectancy of at least 12 months

- Computer capability at home or provided a departmental iPad Mini to borrow for study
purposes

- Primarily English speaking

- Aged 18+ (for which there is available age-adjusted neuropsychological testing
standardization / normative data)

Exclusion Criteria:

- If they are not patients of Massey Cancer Center or do not meet the inclusion criteria
listed above