The Will Erwin Headache Research Center - Cluster Headache Study

The Will Erwin Headache Research Center will assemble a national registry of Cluster Headache
patients and will sub-categorize and organize this cohort based on individuating
characteristics including but not limited to type and severity of condition, associated
symptoms, and medical/psychological issues (e.g., depression, disability, sleep). Detailed
evaluations and classification will be completed for each enrolled subject. This will
encompass genomic and epigenomic studies, past medical history, imaging reports, and specific
physical exam results for each patient. It will also enable the study investigators to match
patients with suitable interventional clinical trials.

Similar diseases, such as other paroxysmal hemicrania, SUNCT, SUNA, hemicrania continua, and
trigeminal neuralgia may also be investigated.

Inclusion Criteria:

- Diagnosis of a trigeminal autonomic cephalalgia according to the International
Headache Classification including episodic cluster headache, chronic cluster headache,
episodic paroxysmal hemicrania, chronic paroxysmal hemicrania, episodic short-lasting
unilateral neuralgiform headache attacks with conjunctival injection and tearing
(SUNCT), chronic SUNCT, episodic short-lasting unilateral neuralgiform headache
attacks with cranial autonomic symptoms (SUNA), chronic SUNA, and hemicrania continua.
OR Diagnosis of a trigeminal neuralgia according to the International Headache
Classification, including classical trigeminal neuralgia and symptomatic trigeminal
neuralgia.

- Able to provide HIPAA authorization to share prior medical records/imaging.

Exclusion Criteria:

- Life expectancy less than 1 year, co-existing disease or other characteristic that
precludes appropriate diagnosis of a trigeminal autonomic cephalalgia or trigeminal
neuralgia.

- Active drug or alcohol use or dependence that, in the opinion of the site
investigator, would interfere with adherence to study requirements

- Inability or unwillingness of subject or legal guardian/representative to give
informed consent.

Inclusion Criteria for Healthy Volunteers:

- Inclusion criteria is willingness to consent and be of age 18 and older