POA Prospective Repository

This repository is a multi-center, outcomes study designed to collect data on the
demographics, presentation, diagnosis, treatment, cost of associated care, quality of life,
and outcomes of subjects utilizing Caris Molecular Intelligence® (CMI) Services for the
treatment of cancer. Prior to enrolling a subject, the subject's physician will have made the
independent decision whether or not to utilize the drug associations provided by CMI and made
clinical treatment choices as appropriate. Thus, data captured and reported provides a "real
world" perspective on diagnosis, treatment, cost, and outcomes.

Prospective data will be obtained only from consented patients or patients who have died or
have been lost to follow-up. Lost to follow-up is defined as a subject who has not returned
for continued care or evaluation (e.g., disability, relocation or unresponsiveness). Site
coordinators are required attempt to contact the subject 3 times before deeming them lost to
follow up. Data collection and the protection of privacy are discussed in the Methods section
below.

In addition to treatment and response data, initial diagnosis and staging results will be
recorded as well as any recurrence information. As we are capturing the subject's cancer
treatment as a whole, results from pertinent cancer-related tests performed by outside
entities for eligible subjects will need to be collected by the site coordinator and
maintained at the site accordingly for reporting and monitoring purposes.

Inclusion Criteria:

- Subject's age must be greater than or equal to 18 years and must have received CMI
testing

Exclusion Criteria:

- Due to the complexity of state and federal requirements governing the participation of
prisoners in research, prisoners-patients shall not be approached for participation.