High Intensity Interval Training in Osteoarthritis, Effects on Metabolomics
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 11/2/2017 |
| Start Date: | January 2017 |
| End Date: | October 2017 |
Feasibility and Initial Effects of High Intensity Interval Training on Knee Osteoarthritis: an Exploratory Evaluation on Metabolomics
Purpose: The purpose of this study will be to examine the feasibility and acceptability of a
6-week high intensity interval training (HIIT) program in patients with knee OA symptoms
ranging from mild to severe. A secondary purpose will be to evaluated changes in whole body
metabolism induced by 6-weeks of HIIT.
Participants: Fifteen patients (age 40-70 yrs; BMI 20-35 kg/m²) with symptomatic knee OA
Procedures (methods): All participants will be assigned to the single-arm of the study in
which all participants will receive 6 weeks of HIIT, delivered twice per week. Outcomes will
be assessed at baseline and 6 weeks. The primary outcome will evaluate tolerability,
feasibility, acceptability, compliance, and adherence to the HIIT program. Secondary outcomes
will include whole body metabolism markers, inflammation, and a set of physical function
including knee osteoarthritis symptomatic burden and pain, cardiorespiratory fitness,
isometric knee extensor and flexor strength (factors associated with physical function and
symptomatic knee OA progression), and body composition.
6-week high intensity interval training (HIIT) program in patients with knee OA symptoms
ranging from mild to severe. A secondary purpose will be to evaluated changes in whole body
metabolism induced by 6-weeks of HIIT.
Participants: Fifteen patients (age 40-70 yrs; BMI 20-35 kg/m²) with symptomatic knee OA
Procedures (methods): All participants will be assigned to the single-arm of the study in
which all participants will receive 6 weeks of HIIT, delivered twice per week. Outcomes will
be assessed at baseline and 6 weeks. The primary outcome will evaluate tolerability,
feasibility, acceptability, compliance, and adherence to the HIIT program. Secondary outcomes
will include whole body metabolism markers, inflammation, and a set of physical function
including knee osteoarthritis symptomatic burden and pain, cardiorespiratory fitness,
isometric knee extensor and flexor strength (factors associated with physical function and
symptomatic knee OA progression), and body composition.
Inclusion Criteria:
- Must exhibit symptomatic knee OA (WOMAC > 31), radiographic evidence of tibiofemoral
OA (2-4 Kellgren-Lawrence scale)
- Age 40-70 years
- Body mass index 20-35 kg/m²
- Cleared by study physician from 12 lead EKG and medical history review
Exclusion Criteria:
- Individuals diagnosed with a cardiovascular condition restricting exercise Individuals
currently meeting Department of Health and Human Services Guidelines for Physical
Activity (meeting >150 minutes of exercise per week)
- Individuals currently doing HIIT
- Individuals currently participating in physical therapy for knee OA
- Individuals currently participating in another OA intervention study
- Received a corticosteroid or hyaluronic acid injection involved in the knee in the
previous 3 weeks or scheduled for during the intervention
- Diagnosis of gout in the knee
- Diagnosis of Rheumatoid arthritis
- Diagnosis of Fibromyalgia
- Other systemic rheumatic disease
- Severe dementia or other memory loss
- Active diagnosis of psychosis or uncontrolled substance abuse disorder
- Hospitalization for a stroke, heart attack, or heart failure, or had surgery for
blocked arteries in the past 6 months
- Diabetics (medications include exogenous insulin)
- Total joint replacement knee surgery, other knee surgery, meniscus tear, or ACL tear
in the past 12 months
- On a waiting list for total joint replacement
- Severely impaired hearing or speech
- Pregnant or planning to become pregnant in the next 8 weeks
- Inability to speak English
- Serious or terminal illness as indicated by referral to hospice or palliative care
- Nursing home residence
- Inability to ride a stationary bike
- Any other health problems that would prohibit safe participation in the study.
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