Spectral Analysis Probe to Identify Glioblastoma Cells

This is a pilot study to investigate if the Chaos Wand Spectral Diagnosis Probe can be used
to identify Glioblastoma (GBM) cancer cells in patients undergoing standard surgical
resection. Eligible patients who have consented to the use of the Chaos Wand will be
scheduled for surgery as standard cancer care for GBM. During the surgical procedure, the
Chaos Wand Spectral Diagnosis Probe will be utilized. Fifteen intraoperative readings and
signal recordings of GBM tissue will be taken. The wand will only be used in areas that have
already been deemed in need of resection due to GBM disease. Each site identified for
spectral analysis will be marked. The wand does not come into contact with the brain at any
point during this procedure. Following surgical resection of the GBM tumor, tissue will be
collected from the same 15 sites where the Chaos Wand was used. The pathology report will be
compared with the results of spectral analysis.

Inclusion Criteria:

1. Male or Female and over 18 years of age.

2. Patients with histologically proven GBM who are newly diagnosed and eligible to
undergo surgical treatment or patients who are suspected of having glioblastoma on
pre-operative imaging which is subsequently confirmed by histopathology following
tumor resection.

3. Patients must be able to understand and willing to sign the informed consent document.

Exclusion Criteria:

1. Patients with absence of glioblastoma.

2. Patients who are not undergoing tumor resection.

3. Patients who have prior brain radiotherapy

4. Patients who have prior systemic chemotherapy

5. Patients who are not willing to sign the informed consent and agree to participate.

6. Patients who are pregnant or nursing