High Dose Bupropion for Smoking Cessation

Participants will be randomly assigned to either receive 300 mg of BUP-XL or 450 mg of BUP-XL
with an aim to quit smoking. They will take the medication for 8 weeks while simultaneously
receiving counseling to set a quit date and stay motivated to quit. Medication will be
administered for 4 weeks before and 4 weeks after designated quit-date. Post-treatment
follow-up appointment will be scheduled for 8, 16, and 26 weeks post treatment so assess
commitment to quitting and overall success of the study.

Inclusion Criteria:

- smokes >= 10 cigarettes per day for >= 2 years

- has breath CO ppm >= 10 ppm on intake

- Age 21 - 65

Exclusion Criteria:

- Past year moderate- severe DSM-5 non-tobacco substance use disorder (4+ symptoms)

- Possible drug contraindications (Panic, bipolar, bulimia, anorexia, insomnia, suicidal
ideation, alcohol withdrawal, seizures, severe hypertension, renal/hepatic impairment,
angle closure glaucoma)

- current use of other cessation medication

- current use of e-cigarettes or other tobacco products > 2X/week

- history of bupropion use

- current anti-psychotic, anxiolytic, antidepressant, or psychostimulant medication use

- currently or plan to be pregnant or breastfeeding