POA Retrospective Repository

This repository is a multi-center, outcomes study designed to retrospectively collect data on
the demographics, presentation, diagnosis, treatment, cost of associated care, quality of
life, and outcomes of subjects utilizing Caris Molecular Intelligence® (CMI) Services for the
treatment of cancer. Prior to enrolling a subject, the subject's physician will have made the
independent decision whether or not to utilize the drug associations provided by CMI and made
clinical treatment choices as appropriate. Thus, data captured and reported provides a "real
world" perspective on diagnosis, treatment, cost, and outcomes.

Patients who have had CMI testing prior to the initial IRB submission date of November 11,
2016 for the respective site would be eligible to have their treatment and treatment response
data entered into the study Database. All entered data would be de-identified. The patient's
CMI biomarker results and treatment response data will be coupled together in order to allow
the investigation of research questions concerning biomarker status and treatment response.

Inclusion Criteria:

- Subject' s age must be greater than or equal to 18 years and must have received CMI
testing prior to the initial protocol IRB submission date of November 11, 2016.

Exclusion Criteria:

- Due to the complexity of state and federal requirements governing the participation of
prisoners in research, prisoners-patients shall not be approached for participation.