Solving Insomnia Electronically: Sleep Treatment for Asthma

Inclusion Criteria:

1. Diagnosis of moderate-severe persistent asthma

2. Clinical diagnosis of asthma based on bronchodilator response or methacholine
challenge testing

3. Not well-controlled asthma

4. Age 18-75 years

5. Meets criteria for Insomnia Disorder

6. At least moderate insomnia severity as evidenced by an Insomnia Severity Index score >
7

7. Telephone, email address, reliable Internet access

8. Stable doses and schedules (i.e., unchanged) of standard therapy for moderate to
severe asthma for 2 months prior to enrollment

9. Have a current primary care physician

10. Stable medical, psychiatric conditions

Exclusion Criteria:

1. Untreated current major depression (Patient Health Questionnaire (PHQ-9) ≥ 10);
patients using stable (3 months) medication treatment are eligible

2. History of bipolar or psychosis

3. Substance abuse disorder within past 3 months

4. Dementia or probable dementia diagnosis

5. High risk for obstructive sleep apnea (OSA), restless legs syndrome (RLS), or delayed
sleep phase disorder (DSPD)

6. Poorly controlled gastroesophageal reflux disease (GERD): Score ≥ 9 on GERD
Questionnaire.

7. Use of oral corticosteroids with dosage of > 10mg/daily during ≥ 4 week period prior
to Visit 1

8. Heavy smoking history

9. Other chronic pulmonary diseases: chronic obstructive lung disease, cystic fibrosis,
or chronic bronchitis

10. Patients experiencing an asthma attack/exacerbation requiring systemic
corticosteroids, hospitalization or emergency room visit during screening/baseline
laboratory visit

11. Use of antibiotics for upper respiratory or pulmonary conditions during ≥ 2 week
period prior to Visit 1

12. Patients who have had > 3 asthma attacks/exacerbations requiring systemic
corticosteroids, hospitalization or emergency room visit within the past year

13. Shift work that includes working the night shift (between the hours of 12:00 a.m. -
6:00 a.m.)

14. Plans to move during the following 6 months

15. Non-English speaking, illiterate, or sensory deficits

16. Currently pregnant. Participants who become pregnant during course of the study will
be withdrawn from the study.