Short Term Choline and Cardiovascular Health
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/6/2019 |
| Start Date: | March 2019 |
| End Date: | May 2020 |
| Contact: | Kevin Davy, PhD |
| Email: | kdavy@vt.edu |
| Phone: | 540-231-3487 |
Short Term Choline Supplementation and Cardiovascular Health in Adults
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary
choline, has recently been causally linked to atherosclerosis in animal models and has been
shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort
studies. The relevance of observations in animals to humans is unclear and little information
is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays
a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO
impairs vascular function in humans is not known. The purpose of this study is to determine
if short term supplementation of dietary choline, which increase TMAO, impairs vascular
function.
choline, has recently been causally linked to atherosclerosis in animal models and has been
shown to be predictive of cardiovascular disease (CVD) risk in some but not all cohort
studies. The relevance of observations in animals to humans is unclear and little information
is available on the mechanisms linking TMAO to increased CVD risk. Vascular dysfunction plays
a critical role in the initiation and progression of atherothrombotic disease. Whether TMAO
impairs vascular function in humans is not known. The purpose of this study is to determine
if short term supplementation of dietary choline, which increase TMAO, impairs vascular
function.
Inclusion Criteria:
- 18-65 years old, healthy, non-smoking weight stable for previous 6 months (±2.0 kg),
BMI<35 kg/m^2, verbal and written informed consent, approved for participation by
study medical director (Jose Rivero, M.D.)
Exclusion Criteria:
- Smoking, pregnancy, obese (BMI>35 kg/m^2), altered dietary patterns within the last
month of recruitment, vegetarians, vegans, unstable heart disease or diabetes,
untreated high blood pressure or high cholesterol, allergies to choline supplement,
taking any medications that could affect the results (ex., aspirin, antibiotics,
pre/probiotics 1 month prior to enrollment), those with trimethylaminuria
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