Examining the Relationship Between Hormone Therapy (HT) and Cognitive Function (The WHIMS-ECHO Study)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 6/8/2018 |
| Start Date: | August 2008 |
| End Date: | November 2021 |
Women's Health Initiative Memory Study--Epidemiology of Cognitive Health Outcomes
This is a prospective, observational study of the cohort of older post-menopausal
participants in the WHI Memory Study, a sub-cohort of participants in the WHI Hormone Trials.
Annual cognitive assessments and ascertainment of cognitive impairment enable the continued
monitoring of long-term effects of randomization to HT on cognition and identification of
predictors of cognitive vulnerability and resilience in older women.
participants in the WHI Memory Study, a sub-cohort of participants in the WHI Hormone Trials.
Annual cognitive assessments and ascertainment of cognitive impairment enable the continued
monitoring of long-term effects of randomization to HT on cognition and identification of
predictors of cognitive vulnerability and resilience in older women.
Identification of the predictors of cognitive impairment and cognitive resilience among aging
women is important because the incidence of mild cognitive impairment (MCI) and dementia
increases with age and women live the longest. The Women's Health Initiative Memory Study
examined the impact of randomization to hormone therapy (conjugated equine estrogen alone or
in combination with medroxyprogesterone vs. placebo) in a subset of participants aged 65-79
years at enrollment into WHI and the WHI Hormone Trials. WHIMS revealed an increased risk of
all-cause dementia and MCI plus poorer global cognitive function among women randomized to HT
compared to those receiving placebo. WHIMS ECHO is a prospective, observational study of the
remaining cohort of WHIMS participants following cessation of treatment. Annual cognitive
assessments of learning, attention, memory, working memory, executive function and language
are conducted by telephone by trained staff and adjudication of incident cognitive impairment
(MCI and dementia) continues. This enables the continued monitoring of long-term effects of
randomization to HT on cognition and identification of predictors of cognitive aging and
resilience in older women.
women is important because the incidence of mild cognitive impairment (MCI) and dementia
increases with age and women live the longest. The Women's Health Initiative Memory Study
examined the impact of randomization to hormone therapy (conjugated equine estrogen alone or
in combination with medroxyprogesterone vs. placebo) in a subset of participants aged 65-79
years at enrollment into WHI and the WHI Hormone Trials. WHIMS revealed an increased risk of
all-cause dementia and MCI plus poorer global cognitive function among women randomized to HT
compared to those receiving placebo. WHIMS ECHO is a prospective, observational study of the
remaining cohort of WHIMS participants following cessation of treatment. Annual cognitive
assessments of learning, attention, memory, working memory, executive function and language
are conducted by telephone by trained staff and adjudication of incident cognitive impairment
(MCI and dementia) continues. This enables the continued monitoring of long-term effects of
randomization to HT on cognition and identification of predictors of cognitive aging and
resilience in older women.
Inclusion Criteria:
- Participated in the WHIMS study
Exclusion Criteria
- Non-English speaking
- Hearing Impaired
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
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